104282-19-1Relevant academic research and scientific papers
Photochemistry of 2-(Trifluoromethyl)cyclohexanone
Semisch, Christoph,Margaretha, Paul
, p. 664 - 668 (1984)
The photochemical behaviour of the title compound 1a is compared to that of the non-fluorinated parent ketone 2-methylcyclohexanone (1b).Substitution of the CH3-group on C(2) by a trifluoromethyl group strongly enhances 2H- and RH-reduction product formation in cyclohexane or 2-propanol and oxetane formation in the presence of 2-methylpropene as olefinic component.Under all these conditions 1b exclusively undergoes α-cleavage, a process observed for 1a only in non-reducing solvents as benzene or tert-butyl alcohol.
An improved synthesis of 2-, 3-, and 4-(trifluoromethyl)cyclohexylamines
Alekseenko, Anatoliy N.,Denis, Klukovsky,Lukin, Oleg,Mykhailiuk, Pavel K.,Shishkin, Oleg V.,Pustovit, Yurii M.
, p. 2739 - 2742 (2012/11/07)
An improved synthesis of 2-, 3-, and 4-trifluoromethylcyclohexylamines on a multigram scale via PtO2-mediated hydrogenation of the corresponding trifluoromethylanilines in trifluoroacetic acid at room temperature under atmospheric pressure is reported. The hydrogenation occurred with a remarkable stereoselectivity favoring the formation of cis-isomers. Georg Thieme Verlag Stuttgart New York.
Facile and selective alkylation of 3,3,3-trifluoropropene oxide (TFPO) with organoaluminum reagents via pentacoordinate trialkylaluminum complexes
Ooi, Takashi,Furuya, Mayumi,Maruoka, Keiji
, p. 817 - 818 (2007/10/03)
A new organoaluminum-promoted selective alkylation of 3,3,3-trifluoropropene oxide (TFPO) with several nucleophiles has been developed which involves the chelation-activated addition to fluoro epoxides via pentacoordinate trialkylaluminum complexes.
Photochemistry of 2-(Perfluoroalkyl)cycloalkanones
Semisch, Christoph,Margaretha, Paul
, p. 471 - 475 (2007/10/02)
In an earlier study we had compared the photochemical behaviour of 2-trifluoromethylcyclohexanone (1a) to that of the non fluorinated parent ketone 2-methylcyclohexanone.Substitution of the methyl group on C(2) by a CF3-group strongly enhances bimolecular reactions such as reductionproduct formation in 2-propanol or oxetane formation in the presence of alkenes.We now report preliminary results on monomolecular photochemical reactions of several 2-(perfluoroalkyl)cycloalkanones.
Trifluoromethyl derivatives of cyclohexanol and cyclohexanone and their reactions
Zalesskaya, I. M.,Blakitnyi, A. N.,Saenko, E. P.,Fialkov, Yu. A.,Yagupol'skii, L. M.
, p. 1031 - 1038 (2007/10/02)
The catalytic hydrogenation of mono- and bistrifluoromethylphenols was investigated, and the structure of the obtained trifluoromethylcyclohexanols was established.Methods were developed for the production of trifluoromethyl derivatives of caprolactam and adipic acid.
