104283-72-9Relevant articles and documents
Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl
Batista, Joo H. C.,Santos, Fernanda M. Dos,Bozzini, Leandro A.,Vessecchi, Ricardo,Oliveira, Alfredo R. M.,Clososki, Giuliano C.
, p. 967 - 977 (2015/02/19)
A variety of difunctionalized aryl-2-oxazolines were prepared from the reaction of halophenyl-2-oxazolines and TMPMgCl?LiCl to give an organomagnesium reagent, which was then treated with various electrophiles. The metalation step takes place under mild conditions, and this process al-lows for the isolation of the desired products in good yields. No isomeric or other benzyne-derived products were detected. The influence of the halogen substituents on the acidity of the aromatic hydrogen atoms was evaluated by using density functional theory (DFT) calculations.