1042907-58-3Relevant academic research and scientific papers
Solvent-controlled regioselective protection of 5′-O-protected thymidine
Teste,Colombeau,Hadj-Bouazza,Lucas,Zerrouki,Krausz,Champavier
, p. 1490 - 1495 (2008/09/20)
This paper describes an efficient procedure for selective 3′-O- or 3-N-protection of 5′-O-tert-butyldimethylsilylthymidine, depending on the use of aprotic polar solvents with low or high dielectric constant, respectively. These syntheses were activated by either ultrasound or microwaves. Several alkyl bromides offer a convenient route to prepare 3′-O- or 3-N-protected and functionalized thymidine derivatives.
