104292-98-0

Basic information

• Product Name: Benzeneacetic acid, 2-(methoxycarbonyl)-a-methyl-, methyl ester
• CAS NO: 104292-98-0
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol File: 104292-98-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, 2-(methoxycarbonyl)-a-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-(methoxycarbonyl)-a-methyl-, methyl ester(104292-98-0)
• EPA Substance Registry System: Benzeneacetic acid, 2-(methoxycarbonyl)-a-methyl-, methyl ester(104292-98-0)

Safety Data

• Hazardous Substances Data: 104292-98-0(Hazardous Substances Data)

Upstream product

• 17639-93-9 2-chloro-propionic acid methyl ester 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 716-43-8 dimethyl homophthalate 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 14736-50-6 o-(methoxycarbonylmethyl)benzoic acid 
• 34939-91-8 dimethyl lithiomethylphosphonate 

Downstream Products

• 40570-19-2 2-(1-carboxyethyl)benzoic acid 
• 1269514-77-3 2-benzyloxy-4-methylisoquinoline-1,3(2H,4H)-dione 

Relevant articles and documents

Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones

We have developed a number of efficient protocols for the facile synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones. This synthetic methodology allowed concise and efficient exploration of the SAR in all areas of the molecule. A number of these methods pro

2-Hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: Influence of the alkylation of position 4

We report herein the synthesis of a series of fifteen 2- hydroxyisoquinoline-1,3(2H,4H)-dione derivatives. Alkyl and arylalkyl groups were introduced on position 4 of the basis scaffold. All the compounds presented poor inhibitory properties against HIV-1 reverse transcriptase ribonuclease H (RNase H). Four compounds inhibited HIV-1 integrase at a low micromolar level. A docking study using the later crystallographic data available for PFV integrase allowed us to explain the slightly improved integrase inhibitory activities of 4-pentyl and 4-(3-phenylpropyl)-2-hydroxyisoquinoline-1,3(2H,4H)-diones, when compared to the basis scaffold. Physicochemical studies were consistent with 1:1 and 1:2 (metal/ligand) stoichiometries of the magnesium complexes in solution. Unfortunately all tested compounds exhibited high cellular cytotoxicity in cell culture which limited their applications as antiviral agents. However these identified integrase inhibitors provide a very good basis for the development of new hits.

An Improved Synthesis of Naphthoate Precursors to Olivin

An improved synthesis of olivin synthetic intermediate 3 is described.The synthesis involves the Horner-Wadsworth-Emmons coupling of 14 and 16, the diastereoselective vinylcuprate addition to enone 20, and the condensation of isocoumarin 25 and methyl acetate.A parallel sequence starting from allyl ether 26 has provided naphthoate 35 that is suitably differentiated for glycosylation studies.