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104293-76-7

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104293-76-7 Usage

General Description

Ethyl 8-hydroxyquinoline-5-carboxylate, also known as oxine or oxine ethyl ether, is an organic compound with the molecular formula C15H13NO3. It is a derivative of 8-hydroxyquinoline, with an ethyl ester group and a carboxylate group on the 5th and 8th positions, respectively. This chemical is commonly used as a chelating agent and metal ion indicator, due to its ability to form stable complexes with metals such as aluminum, zinc, and iron. It is also used as a reagent in analytical chemistry and as a building block in the synthesis of various pharmaceuticals and organic compounds. Ethyl 8-hydroxyquinoline-5-carboxylate is considered a potentially hazardous substance and should be handled with care.

Check Digit Verification of cas no

The CAS Registry Mumber 104293-76-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,2,9 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 104293-76:
(8*1)+(7*0)+(6*4)+(5*2)+(4*9)+(3*3)+(2*7)+(1*6)=107
107 % 10 = 7
So 104293-76-7 is a valid CAS Registry Number.

104293-76-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 8-hydroxyquinoline-5-carboxylate

1.2 Other means of identification

Product number -
Other names ethyl-8-hydroxyquinoline-5-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:104293-76-7 SDS

104293-76-7Downstream Products

104293-76-7Relevant articles and documents

A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1

Schiller, Rachel,Scozzafava, Giuseppe,Tumber, Anthony,Wickens, James R.,Bush, Jacob T.,Rai, Ganesha,Lejeune, Clarisse,Choi, Hwanho,Yeh, Tzu-Lan,Chan, Mun Chiang,Mott, Bryan T.,McCullagh, James S. O.,Maloney, David J.,Schofield, Christopher J.,Kawamura, Akane

, p. 566 - 571 (2014)

The 2-oxoglutarate (2OG)-dependent Jumonjia C domain (JmjC) family is the largest family of histone lysine demethylases. There is interest in developing small-molecule probes that modulate JmjC activity to investigate their biological roles. 5-Carboxy-8-hydroxyquinoline (IOX1) is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, reported to date; however, it suffers from low cell permeability. Here, we describe structure-activity relationship studies leading to the discovery of an n-octyl ester form of IOX1 with improved cellular potency (EC50 value of 100 to 4a μM). These findings are supported by in vitro inhibition and selectivity studies, docking studies, activity versus toxicity analysis in cell cultures, and intracellular uptake measurements. The n-octyl ester was found to have improved cell permeability; it was found to inhibit some JmjC demethylases in its intact ester form and to be more selective than IOX1. The n-octyl ester of IOX1 should find utility as a starting point for the development of JmjC inhibitors and as a use as a cell-permeable tool compound for studies investigating the roles of 2OG oxygenases in epigenetic regulation.

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