1042986-18-4

Basic information

• Product Name: 2-Chloro-5-cyclopropylpyridine
• Synonyms: 2-Chloro-5-cyclopropylpyridine
• CAS NO: 1042986-18-4
• Molecular Formula: C8H8ClN
• Molecular Weight: 153.60882
• Mol File: 1042986-18-4.mol

Chemical Properties

• Boiling Point: 237.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.252±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.48±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-5-cyclopropylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-cyclopropylpyridine(1042986-18-4)
• EPA Substance Registry System: 2-Chloro-5-cyclopropylpyridine(1042986-18-4)

Safety Data

• Hazardous Substances Data: 1042986-18-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Chloro-5-cyclopropylpyridine is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its presence in the molecule allows for the creation of a wide range of compounds with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Chloro-5-cyclopropylpyridine is used as a key intermediate in the synthesis of pyridine derivatives and other heterocyclic compounds. Its ability to modulate biological targets and exhibit diverse pharmacological properties makes it valuable in the development of new drugs.
Used in Medicinal Chemistry:
2-Chloro-5-cyclopropylpyridine is utilized in medicinal chemistry for its potential applications in modulating biological targets. Its diverse pharmacological properties contribute to the development of new drugs and chemical tools for research purposes, enhancing the discovery of novel therapeutic agents.

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 893738-68-6 2-amino-5-cyclopropylpyridine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 411235-57-9 cyclopropylboronic acid 

Relevant articles and documents

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The reactions of 2-amino-5-cyclopropylpyridine with organic nitrites in the presence of copper(II) halides in various organic solvents were investigated. Optimal reaction conditions for the Sandmeyer reaction were developed and successfully applied to the synthesis of useful building blocks, bromo and chlorocyclopropylpyridines. Aminocyclopropylpyridines were synthesized in high yields from the corresponding aminobromopyridines under standard Suzuki coupling conditions.

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