1043023-92-2Relevant articles and documents
Studies on the antioxidant activity of some thiazolidinedione, imidazolidinedione and rhodanine derivatives having a flavone core
Berczyński, Pawe?,K?adna, Aleksandra,Piechowska, Teresa,Kruk, Irena,Bozda?-Dündar, Oya,Aboul-Enein, Hassan Y.,Ceylan-Unlusoy, Meltem,Ertan, Rahmiye
, p. 1107 - 1112 (2014)
A series of flavonyl-2,4-thiazolidinedione, imidazolidinedione and rhodanine derivatives were tested for their antioxidant activity as scavengers of oxygen free radicals. Free radical scavenging activities, including superoxide anion radical (O-2), hydroxyl radical (HO?) and 2,2′-diphenyl-1-picrylhydrazyl free radical have been evaluated using chemiluminescence, electron paramagnetic resonance and spin trapping with 5,5-dimethyl-1-pyrroline-1-oxide as a spin trap. Potassium superoxide in dimethylsulfoxide and 18-crown-6 ether were used for the production of O-2. Hydroxyl radical was generated using the Fenton reaction. Ten of the eleven examined compounds exhibited decrease in chemiluminescence, but there were large differences in the decrease, ranging from 16% to 89%; also, two of these compounds increased light emission by about 200%. On the contrary, all compounds tested exhibited 30-68% scavenging HO? and 25-96% scavenging the DPPH radical respectively. Possible mechanisms are proposed to explain the results.