104309-80-0

Basic information

• Product Name: thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid
• Synonyms: thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid
• CAS NO: 104309-80-0
• Molecular Weight: 346.425
• Mol File: 104309-80-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid(104309-80-0)
• EPA Substance Registry System: thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid(104309-80-0)

Safety Data

• Hazardous Substances Data: 104309-80-0(Hazardous Substances Data)

Upstream product

• 131270-64-9 diethylammonium 5,5-dimethyl-3-oxo-2-<2-thiocarbamoyl-1-(4-fluorophenyl)-2-cyanoethyl>-1-cyclohexen-1-olate 
• 131270-62-7 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with piperidine 
• 131270-65-0 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with morpholine 
• 131270-63-8 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with azepane 

Downstream Products

• 107752-99-8 2-amino-4-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile 
• 104309-82-2 7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-5,6,7,8-tetrahydro-2(1H)-quinolinethione 
• 104309-83-3 3-amino-2-benzoyl-7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-4,5,6,7,8,9-hexahydrothieno<2,3-b>quinoline 
• 104309-81-1 cis-7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethione 
• 117822-65-8 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran 
• 104309-81-1 7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethione 
• 131270-81-0 4-(4-Fluoro-phenyl)-2-mercapto-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline-3-carbonitrile; compound with morpholine 

Relevant articles and documents

CYCLIZATION REACTIONS OF NITRILES. XXVII. THE STRUCTURE AND CONFORMATIONALLY AMBIDENT HETEROCYCLIZATION OF SUBSTITUTED 2-(THIOCARBAMOYL-2-CYANOETHYL)-3-OXO-1-CYCLOHEXENOLATES

The reaction of arylmethylenecyanoacetamides with dimedone in the presence of bases proceeds with the formation of anti isomers of derivatives of ammonium 2-(2-thiocarbamoyl-2-cyanoethyl)-3-oxo-1-cyclohexen-1-olate.The ambident cyclization of these compou