104309-83-3

Upstream product

• 131270-62-7 2-Cyano-3-(4-fluoro-phenyl)-3-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-thiopropionamide; compound with piperidine 
• 104309-80-0 thioamide of 3-(5,5-dimethyl-1-hydroxy-3-oxo-1-cyclohexen-2-yl)-3-(4-fluorophenyl)-2-cyanopropionic acid 
• 117822-65-8 2-amino-7,7-dimethyl-5-oxo-3-thiocarbamoyl-4-(4-fluorophenyl)-5,6,7,8-tetrahydro-4H-benzopyran 
• 126-81-8 dimedone 
• 97579-25-4 2-cyano-3-(4-fluorophenyl)prop-2-enethioamide 
• 104309-81-1 cis-7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethione 
• 70-11-1 α-bromoacetophenone 
• 104309-81-1 7,7-dimethyl-5-oxo-4-(4-fluorophenyl)-3-cyano-3,4,5,6,7,8-hexahydro-2(1H)-quinolinethione 

Relevant academic research and scientific papers

CYCLIZATION OF NITRILES. XXI. SUBSTITUTED 4-(3-PYRIDYL)- AND 4-(4-PYRIDYL)-3-CYANO-2(1H)-PYRIDINETHIONES

The reaction of pyridylmethylenecyanothioacetamides with carbonyl compounds, enamines, and enamino ketones gave substituted 4-(3-pyridyl)- and 4-(4-pyridyl)-3-cyano-2(1H)-pyridinethiones and their hydrogenated analogs.The direction of the transformation is determined by the structure of the initial reagents.From a detailed study of the reactions a method was developed for the synthesis of derivatives of 4-(3-pyridyl)- and 4-(4-pyridyl)-3-cyano-2(1H)-pyridinethiones involving three-component condensation of aldehydes of the pyridine series, carbonyl compounds, and cyanothioacetamide.