10431-83-1Relevant academic research and scientific papers
Facile one-pot synthesis of 2-oxazoline
Zhu, Jipeng,Zhou, Min,Jiang, Weinan,Zhou, Yang,Song, Gonghua,Liu, Runhui
supporting information, (2022/01/28)
We developed a facile one-pot synthesis of 2-oxazolines from carboxylic acid and 2-chloroethyl isocyanate, involving amide bond formation and a following intramolecular cyclization using 4-dimethylaminopyridine as the catalyst. A large variety of functional groups are well tolerated by the mild reaction conditions to afford diverse 2-oxazolines in good to excellent yields. This reaction will keep the chirality of the isocyanate at position 1, the R2 substituted carbon. Microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time to 5 min. This method facilities the synthesis of 2-oxazolines for diverse applications, such as 2-oxazoline derived polymers and materials.
An efficient oxidative conversion of aldehydes into 2-substituted 2-oxazolines using 1,3-diiodo-5,5-dimethylhydantoin
Takahashi, Shogo,Togo, Hideo
experimental part, p. 2329 - 2332 (2010/03/01)
Various aromatic and aliphatic aldehydes were converted into the corresponding 2-aryl and 2-alkyl-2-oxazolines, respectively, in good to high yields by reaction with 2-aminoethanol and 1,3-diiodo-5,5-dimethylhydantoin. Moreover, chiral bis-2-oxazolines, which can be used as chiral ligands in asymmetric synthesis, could be also prepared in moderate yields by the reaction of dialdehydes with (R)-(-)-2-phenylglycinol under the same conditions. Georg Thieme Verlag Stuttgart.
Convenient one-pot synthesis of 2-oxazolines from carboxylic acids
Hioki, Kazuhito,Takechi, Yumiko,Kimura, Noriyo,Tanaka, Hiroyuki,Kunishima, Munetaka
experimental part, p. 1735 - 1737 (2009/10/10)
Simple one-pot methods for preparation of 2-oxazolines have been developed using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). Treatment of a mixture of carboxylic acids and 2-haloethylammonium salts with DMT-MM in methanol
Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine
Ishihara, Midori,Togo, Hideo
, p. 1474 - 1480 (2007/10/03)
Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.
The Use of 2-Oxazolidinone as a Latent Aziridine Equivalent. I. A Facile Method for the Preparation of 2-Substituted Oxazolines
Poindexter, Graham S.
, p. 1431 - 1433 (2007/10/02)
Ring-opening reaction of 2-oxazolidinone with acid chlorides followed by treatment with aqueous sodium hydroxide yields 2-substituted oxazolines.
