10431-99-9

Basic information

• Product Name: 2-ISOPROPYL-2-OXAZOLINE
• Synonyms: 2-ISOPROPYL-2-OXAZOLINE
• CAS NO: 10431-99-9
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.16
• Mol File: 10431-99-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 138 °C
• Flash Point: 32.4°C
• Appearance: /
• Density: 0.95
• Vapor Pressure: 10.1mmHg at 25°C
• Refractive Index: 1.4330 to 1.4380
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-ISOPROPYL-2-OXAZOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ISOPROPYL-2-OXAZOLINE(10431-99-9)
• EPA Substance Registry System: 2-ISOPROPYL-2-OXAZOLINE(10431-99-9)

Safety Data

• RIDADR: UN 1993 3/PG III
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 10431-99-9(Hazardous Substances Data)

Usage

General Description

2-Isopropyl-2-oxazoline is a chemical compound that is primarily used as a monomer in the production of polymers. It is a clear, colorless liquid with a faint odor, and it is highly soluble in water. 2-ISOPROPYL-2-OXAZOLINE is commonly employed in the manufacture of coatings, adhesives, and industrial resins due to its ability to improve the durability and flexibility of these materials. Additionally, 2-isopropyl-2-oxazoline has been found to have antibacterial and antifungal properties, making it a useful ingredient in some personal care and pharmaceutical products. Overall, this chemical plays a crucial role in various industrial processes and applications across different sectors.

InChI:InChI=1/C6H11NO/c1-5(2)6-7-3-4-8-6/h5H,3-4H2,1-2H3

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Relevant articles and documents

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In Vitro Assessment of the Hydrolytic Stability of Poly(2-isopropenyl-2-oxazoline)

Poly(2-isopropenyl-2-oxazoline) (PiPOx) is emerging as a promising, versatile polymer platform to design functional materials and particularly biomaterials that rely on the hydrophilic character of the 2-oxazoline side units. To be able to assess the applicability of PiPOx in a biomedical context, it is essential to understand its stability and degradation behavior in physiological conditions. In the present work, the hydrolytic stability of PiPOx was systematically investigated as a function of pH during incubation in various buffers. PiPOx was found to be stable in deionized water (pH 6.9), to have good stability in basic conditions (pH 8 and 9), to be satisfactorily stable in neutral conditions (pH 7.4), and to have moderate to low stability in acidic conditions (decreases drastically from pH 6 to pH 1.2). At pH 4, PiPOx formed a crosslinked network in a timeframe of hours, while at pH 1.2, PiPOx was transformed to a water-soluble poly(N-(2-hydroxyethyl)methacrylamide) type of structure over the course of 2 weeks. In vitro stability assays were performed in phosphate-buffered saline (pH 7.4), simulated body fluid (SBF) (pH 7.4), simulated saliva (pH 6.4), simulated intestinal fluid (pH 6.8), and plasma (pH 7.4) revealing that PiPOx is stable in these SBFs up to 1 week of incubation. When incubated in simulated gastric fluid (pH 1.2), PiPOx exhibited a similar degradation behavior to that observed in the buffer at pH 1.2, rendering a water-soluble structure. The presented results on the stability of PiPOx will be important for future use of PiPOx for the development of drug-delivery systems and biomedical applications, such as hydrogels.

Versatile synthesis of end-functionalized thermosensitive poly(2-isopropyl-2-oxazolines)

The synthesis of several end-functionalized poly(2-isopropyl-2-oxazolines) (PiPrOx) has been achieved via cationic ring-opening polymerization of 2-isopropyl-2-oxazoline. Poly(2-isopropyl-2-oxazolines) bearing primary amino groups at one chain end (Me-PiP