10433-88-2

Upstream product

• 6322-49-2 4-chloro-2-butanone 
• 62116-54-5 sodium diethyl methylmalonate 
• 78-94-4 methyl vinyl ketone 
• 609-08-5 Diethyl methylmalonate 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1405680-34-3 (±)-ethyl 5-(2,4-dinitrophenoxyimino)-2-methylhexanoate 
• 108011-36-5 3,6-Dimethyl-cyclohexan-⁽¹⁾-on-2,3-dicarbonsaeure-diaethylester 
• 108010-82-8 3,6-Dimethyl-6-(2-methoxycarbonyl-ethyl)-cyclohexanon-3-carbonsaeure-methylester 
• 91766-13-1 1,4-Dimethyl-3-oxo-cyclohexan-1,2-dicarbonsaeure-dimethylester 
• 104177-28-8 3.6-Dimethyl-cyclohexan-1-on-3-carbonsaeure-aethylester 
• 91057-28-2 1.4-Dimethyl-3-oxo-cyclohexan-carbonsaeure-⁽¹⁾-methylester 
• 100619-00-9 3,6-Dimethyl-6-(2-cyanaethyl)-cyclohexanon-3-carbonsaeure-methylester 
• 99862-43-8 3.6-Dimethyl-6-brom-cyclohexanon-3-carbonsaeure-aethylester 
• 24730-94-7 ethyl 1-methyl-2,4-dioxocyclohexane-1-carboxylate 

Relevant academic research and scientific papers

NUCLEOPHILIC RING OPENING OF DIETHYL 1,1-CYCLOPROPANEDICARBOXYLATE USING Na2Fe(CO)4*3/2 DIOXANE

Diethyl 1,1-cyclopropanedicarboxylate undergoes nucleophilic ring opening with Na2Fe(CO)4*3/2 dioxane under CO at room temperature to produce a variety of carbonylated products.

Nickel/zinc chloride-promoted domino reaction of enynes and enones including unstrained C-C bond cleavage

Unstrained C-C bond cleavage proceeds during the domino reaction of enynes and enones that includes successive C-C bond formation under the nickel/zinc/zinc chloride system. The cleavage occurs through β-syn-elimination of the 1,3-dicarbonyl part. In addition, β-carbon elimination is selective, unlike the β-hydrogen elimination in the presence of excess zinc chloride. Copyright

BENZOQUINOLONE INHIBITORS OF VMAT2

The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof represented by structural Formula I.

METHODS OF TREATING ABNORMAL MUSCULAR ACTIVITY

Methods for treating abnormal muscular activity are disclosed. The methods may be performed remotely and permit monitoring of a subject outside a healthcare provider's office.

BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof. (I)

Rapid synthesis of substituted pyrrolines and pyrrolidines by nucleophilic ring closure at activated oximes

Substituted pyrrolines are available by ring closure initiated by direct nucleophilic attack of stabilized enolates at the nitrogen of oximes activated with a leaving group, in a process which effectively out-competes the more usual Beckmann rearrangement. Subsequent reduction provides diastereoselective access to the corresponding pyrrolidines. This provides a rapid route to saturated heterocyclic systems from readily available precursors.

Phosphine-boronates: Efficient bifunctional organocatalysts for Michael addition

Phosphine-boronates R2P(o-C6H4) B(OR′)2 have been evaluated as bifunctional organocatalysts for the Michael addition of malonate pronucleophiles to methylvinylketone. The presence of the Lewis acidic boron center adjacent to phosphorus significantly improves catalytic performance. Isolation and complete characterization of a key intermediate, namely a β-phosphonium enolate, substantiate the role of the Lewis acidic moiety in the catalytic process.

N-heterocyclic carbene-catalyzed michael additions of 1,3-dicarbonyl compounds

A study of the organocatalytic activity of N-heterocyclic carbenes (NHCs) in the Michael addition of 1,3-dicarbonyl compounds has allowed us to identify 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene (IPr) as an excellent catalyst for this transformatio

Highly efficient C-C bond-forming reactions in aqueous media catalyzed by monomeric vanadate species in an apatite framework

A calcium vanadate apatite (VAp), in which PO43- of hydroxyapatite (HAP), Ca10(PO4)6(OH) 2, is completely substituted by VO43- in the apatite framework, was synthesized. Physicochemical analysis of the VAp reveals the presence of isolated VO4 tetrahedron units with a pentavalent oxidation state. The VAp acts as a high-performance heterogeneous base catalyst for various carbon-carbon bond-forming reactions such as Michael and aldol reactions in aqueous media and the H-D exchange reactions using deuterium oxide. For example, a 200-mmol-scale Michael reaction under triphasic conditions proceeded rapidly, with an extremely high turnover number of up to 260 400 and an excellent turnover frequency of 48 s-1. No vanadium leaching was detected during the above reactions, and the catalyst was readily recycled with no loss of activity.

Photoisomerization of 4-Hydroxypyrylium Cations in Concentrated Sulfuric Acid

Irradiation of di-, tri-, and tetraalkyl-4-hydroxypyrylium cations in concentrated sulfuric acid leads to the formation of 2-hydroxypyrylium cations as phototransposition products and, in certain cases, to furyl cations by a photo-ring-contraction reaction.Product analysis by spectroscopic techniques, deuterium labeling, and unambiguous synthesis reveals that 2-hydroxypyrylium cations are formed by two distinct transposition patterns and accordingly, by two distinct mechanistic pathways.The bond-forming and -breaking requirements of the major transposition pattern, which constitutes approximately 95percent of the reaction, are consistent with a mechanism initiated by 2,6-bridging in the first excited state of the 4-hydroxypyrylium cation.Similarly, the bond-formation and -breaking requirements of the minor pattern are consistent with a mechanism involving 2,5-bridging in the first excited state of the starting cation.