104330-40-7Relevant academic research and scientific papers
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection
Kim, Dooseop,Wang, Liping,Caldwell, Charles G.,Chen, Ping,Finke, Paul E.,Oates, Bryan,MacCoss, Malcolm,Mills, Sander G.,Malkowitz, Lorraine,Gould, Sandra L.,DeMartino, Julie A.,Springer, Martin S.,Hazuda, Daria,Miller, Michael,Kessler, Joseph,Danzeisen, Renee,Carver, Gwen,Carella, Anthony,Holmes, Karen,Lineberger, Janet,Schleif, William A.,Emini, Emilio A.
, p. 3099 - 3102 (2007/10/03)
A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.
SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
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, (2008/06/13)
The present invention is directed to spiro-substituted azacycles of the Formula 1: STR1 (wherein R 1, l, m, Q, W, X, Y, and Z are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
2-aminomethyltetrahydrofurans, fungicidal compositions and use
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, (2008/06/13)
Fungicidally active 2-aminomethyltetrahydrofurans of the formula STR1 in which R1 represents in each case optionally substituted aryl, heteroaryl, cycloalkyl, tetrahydronaphthyl or decahydronaphthyl; R2 represents hydrogen or methyl;
ALLYLATION AND OXIDATION REACTIONS PROMOTED BY COBALT(ll) COMPLEXES.
Gaudemer, A.,Nguyen-Van-Duong, K.,Shahkarami, N.,Achi, S. S.,Frostin-Rio, M.,Pujol, D.
, p. 4095 - 4106 (2007/10/02)
Two examples of radical reactions involving cobalt complexes are described.The first one concerns the reactions of allylcobaloximes with 2-bromo 2-phenylacetonitriles leading to the corresponding monoallyl derivatives.It is shown that both the rate and regioselectivity of the reactions are affected by the nature of the substituents on the phenyl group : electron-withdrawing groups give higher rates and highly regiospecific reactions.The second type of radical reactions wich finds useful synthetic applications is the oxidation of phenols by O2 catalysed by Schiff base cobalt complexes.By choosing carefully the catalyst and the solvent, these oxidations can be highly selective, quinones being the major oxidation products in most cases.
