90775-14-7Relevant academic research and scientific papers
Histamine H1 receptor ligands - Part II. Synthesis and in vitro pharmacology of 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives
Walczynski, Krzysztof,Guryn, Roman,Zuiderveld, Obbe P.,Zhang, Ming-Qiang,Timmerman, Henk
, p. 569 - 574 (2007/10/03)
New 2-[2-(phenylamino)thiazol-4-yl]ethanamine and 2-(2-benzhydrylthiazol-4-yl)ethanamine derivatives were prepared and tested in vitro as H1 receptor antagonists. The compounds with 2-phenylamino substitution with meta-halide substituents at the phenyl ring, showed weak H1-antagonistic activity (pA2: 4.62-5.04) and this activity was completely lost in the case of meta-methyl substituent (pA2 : 4). When the phenylamino group was replaced by benzhydryl groups of classic antihistamines, the resulting compounds exhibited slightly improved H1-antagonistic activity (at the meta-position pA2: 6.38-6.15; at the para-position pA2: 6.04-5.87).
ALLYLATION AND OXIDATION REACTIONS PROMOTED BY COBALT(ll) COMPLEXES.
Gaudemer, A.,Nguyen-Van-Duong, K.,Shahkarami, N.,Achi, S. S.,Frostin-Rio, M.,Pujol, D.
, p. 4095 - 4106 (2007/10/02)
Two examples of radical reactions involving cobalt complexes are described.The first one concerns the reactions of allylcobaloximes with 2-bromo 2-phenylacetonitriles leading to the corresponding monoallyl derivatives.It is shown that both the rate and regioselectivity of the reactions are affected by the nature of the substituents on the phenyl group : electron-withdrawing groups give higher rates and highly regiospecific reactions.The second type of radical reactions wich finds useful synthetic applications is the oxidation of phenols by O2 catalysed by Schiff base cobalt complexes.By choosing carefully the catalyst and the solvent, these oxidations can be highly selective, quinones being the major oxidation products in most cases.
