1043451-54-2Relevant articles and documents
Total synthesis of GEX1A
Murray, Timothy J.,Forsyth, Craig J.
, p. 3429 - 3431 (2008)
(Chemical Equation Presented) An efficient and readily modifiable synthesis of GEX1A/herboxidiene/TAN-1609 (1) was developed. This modular synthesis featured a Suzuki coupling to install the conjugated diene and a Ru-catalyzed lactonization and Roush crotylation to construct the functionalized tetrahydropyran moiety. Myers' alkylation, cross-metathesis, and Keck crotylation were employed for assembly of the biologically essential side-chain domain.