1043451-65-5Relevant academic research and scientific papers
Regulation of cholesterol homeostasis
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Page/Page column 16; 17, (2014/10/29)
The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.
Total synthesis of GEX1A
Murray, Timothy J.,Forsyth, Craig J.
supporting information; experimental part, p. 3429 - 3431 (2009/05/11)
(Chemical Equation Presented) An efficient and readily modifiable synthesis of GEX1A/herboxidiene/TAN-1609 (1) was developed. This modular synthesis featured a Suzuki coupling to install the conjugated diene and a Ru-catalyzed lactonization and Roush crotylation to construct the functionalized tetrahydropyran moiety. Myers' alkylation, cross-metathesis, and Keck crotylation were employed for assembly of the biologically essential side-chain domain.
