159572-27-7Relevant articles and documents
BRYOSTATIN ANALOGS AND USE THEREOF AS ANTIVIRAL AGENTS
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Paragraph 0232; 0233, (2016/02/29)
Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in a low number of steps and with a high degree of substitution and specificity.
Regulation of cholesterol homeostasis
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Page/Page column 16; 17, (2014/10/29)
The invention provides novel compounds of Formulas (I)-(IV), as described herein. Also provided are compositions of these compounds, method of making the compounds, and methods of using the compounds. The compounds can be used to regulate cholesterol homeostasis and to treat conditions and diseases associated with cholesterol homeostasis, including lysosomal lipid storage disorders such as Niemann-Pick Disease type C.
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]
Bennett, Frank,Saksena, Anil K.,Lovey, Raymond G.,Liu, Yi-Tsung,Patel, Naginbhai M.,Pinto, Patrick,Pike, Russel,Jao, Edwin,Girijavallabhan, Viyyoor M.,Ganguly, Ashit K.,Loebenberg, David,Wang, Haiyan,Cacciapuoti, Anthony,Moss, Eugene,Menzel, Fred,Hare, Roberta S.,Nomeir, Amin
, p. 186 - 190 (2007/10/03)
As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies.
