1043476-31-8

Basic information

• Product Name: C₂₁H₂₅F₃N₂O₂S
• CAS NO: 1043476-31-8
• Molecular Weight: 426.503
• Mol File: 1043476-31-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₅F₃N₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₅F₃N₂O₂S(1043476-31-8)
• EPA Substance Registry System: C₂₁H₂₅F₃N₂O₂S(1043476-31-8)

Safety Data

• Hazardous Substances Data: 1043476-31-8(Hazardous Substances Data)

Upstream product

• 15084-51-2 4-tert-butylbenzenesulfonyl chloride 
• 63854-31-9 1-[2-(trifluoromethyl)phenyl]piperazine 

Relevant articles and documents

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).