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63854-31-9

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63854-31-9 Usage

General Description

1-(2-Trifluoromethylphenyl)-piperazine is a chemical compound with the molecular formula C11H14F3N. It is a piperazine derivative, which is commonly used in the synthesis of pharmaceutical drugs and research chemicals. 1-(2-TRIFLUOROMETHYLPHENYL)-PIPERAZINE contains a piperazine ring with a phenyl group and a trifluoromethyl group attached to it. The trifluoromethyl group is known for its electron-withdrawing properties, which can make the compound more stable and potent. 1-(2-Trifluoromethylphenyl)-piperazine has been studied for its potential as a serotonin receptor agonist, and it also shows some antipsychotic and anxiolytic effects in preclinical studies. However, it should be handled with caution due to its potential for toxic and harmful effects if not used properly.

Check Digit Verification of cas no

The CAS Registry Mumber 63854-31-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,3,8,5 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 63854-31:
(7*6)+(6*3)+(5*8)+(4*5)+(3*4)+(2*3)+(1*1)=139
139 % 10 = 9
So 63854-31-9 is a valid CAS Registry Number.

63854-31-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-Trifluoromethylphenyl)piperazine

1.2 Other means of identification

Product number -
Other names 1-[2-(trifluoromethyl)phenyl]piperazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:63854-31-9 SDS

63854-31-9Relevant articles and documents

PYRIDAZINONES AND METHODS OF USE THEREOF

-

Page/Page column 273, (2019/04/11)

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Identification of novel GLUT inhibitors

Siebeneicher, Holger,Bauser, Marcus,Buchmann, Bernd,Heisler, Iring,Müller, Thomas,Neuhaus, Roland,Rehwinkel, Hartmut,Telser, Joachim,Zorn, Ludwig

, p. 1732 - 1737 (2016/07/27)

The compound class of 1H-pyrazolo[3,4-d]pyrimidines was identified using HTS as very potent inhibitors of facilitated glucose transporter 1 (GLUT1). Extensive structure–activity relationship studies (SAR) of each ring system of the molecular framework was established revealing essential structural motives (i.e., ortho-methoxy substituted benzene, piperazine and pyrimidine). The selectivity against GLUT2 was excellent and initial in vitro and in vivo pharmacokinetic (PK) studies are encouraging.

Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1)

Sun, Daqing,Wang, Zhulun,Di, Yongmei,Jaen, Juan C.,Labelle, Marc,Ma, Ji,Miao, Shichang,Sudom, Athena,Tang, Liang,Tomooka, Craig S.,Tu, Hua,Ursu, Stefania,Walker, Nigel,Yan, Xuelei,Ye, Qiuping,Powers, Jay P.

scheme or table, p. 3513 - 3516 (2009/04/11)

High-throughput screening of a small-molecule compound library resulted in the identification of a series of arylsulfonylpiperazines that are potent and selective inhibitors of human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1). Optimization of the initial lead resulted in the discovery of compound (R)-45 (11β-HSD1 IC50 = 3 nM).

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