104356-17-4

Usage

Uses

Used in Organic Synthesis:
4-Bromo-2-(trifluoromethyl)benzoyl chloride is used as a reagent for the introduction of the benzoyl chloride moiety into various organic molecules. Its reactivity allows for the formation of new chemical bonds and the synthesis of a wide range of organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-Bromo-2-(trifluoromethyl)benzoyl chloride is used as a key intermediate in the synthesis of various drugs. Its unique structure and functional groups contribute to the development of new pharmaceuticals with specific therapeutic properties.
Used in Agrochemical Production:
4-Bromo-2-(trifluoromethyl)benzoyl chloride is also utilized in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these chemicals can enhance their effectiveness and selectivity in controlling pests and weeds.
Used in Specialty Chemicals:
4-Bromo-2-(trifluoromethyl)benzoyl chloride serves as an intermediate in the synthesis of complex organic compounds and materials used in various specialty chemical applications. Its unique properties and reactivity enable the development of innovative products with specific performance characteristics.

Upstream product

• 211796-64-4 4-dibromo-2-(trifluoromethyl)benzaldehyde 
• 320-31-0 4-bromo-2-(trifluoromethyl)benzoic acid 

Downstream Products

• 530088-97-2 methyl (2Z)-{1-[4-bromo-2-(trifluoromethyl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}acetate 
• 1035928-54-1 t-butyl 2-[4-bromo-2-(trifluoromethyl)benzoyl]hydrazinecarboxylate 
• 1197231-94-9 1-(4-bromo-2-(trifluoromethyl)phenyl)ethan-1-one 
• 123524-61-8 4-bromo-2-(trifluoromethyl)benzamide 
• 873846-15-2 N,N,4-triethyl-2-(trifluoromethyl)benzamide 

Relevant academic research and scientific papers

2-benzoyl malonate compound as well as preparation method and application thereof

The invention discloses a 2-benzoyl malonate compound as well as a preparation method and application thereof. The invention provides a preparation method of an acetylbenzene compound shown as a formula III. The preparation method comprises the following step: in an organic solvent, in the presence of an acid and water, carrying out a deesterification reaction as shown in the specification on a 2-benzoyl malonate compound as shown in a formula I and/or a tautomer thereof to obtain the acetylbenzene compound as shown in a formula III, wherein X is F, Cl, Br or I; wherein R1 and R2 are each independently a C1-C4 alkyl group. By adopting the 2-benzoyl malonate compound disclosed by the invention, 4-halogenated-2-trifluoromethyl acetophenone can be prepared through one-step reaction, and the operation is simple and convenient.

Benzamide compounds containing acetenyl group

The invention provides acetenyl group-containing benzamide compounds as shown in a formula (I) and used for treating or preventing diseases related to protein kinase, and medicinal salts or configurational isomers thereof. A connection group L, a ring A and substituents R, R, R, R and R in the formula (I) are as defined in the specification. The invention also discloses a preparation method and a pharmaceutical composition of the compounds as shown in the formula (I), and application of the compounds to preparation or prevention of drugs used for preventing diseases related to protein kinase.

NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN, ETC

The present invention provides compounds useful as c-Met protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of c-Met kinase mediated disease or disorders with them.

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin- 5(9bH)-ones as 5-HT2C receptor agonists

A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT2C agonism with excellent selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compounds such as 38 and 44 were shown to be effective in reducing food intake in an acute rat feeding model.

4,4-DIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE DERIVATIVES OR SALTS THEREOF

4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine derivatives, which have excellent arginine vasopressin V2 activity and are useful for a drug for the treatment of central diabetes insipidus and/or nocturia.