104380-26-9

Upstream product

• 104362-85-8 (3S,4S)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-methoxycarbonyl-2-azetidinone 
• 86258-97-1 (3S,4S)-4-carboxy-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-2-azetidinone 
• 501-53-1 benzyl chloroformate 
• 104362-86-9 (3S,4S)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-(1-hydroxy-1-methylethyl)-2-azetidinone 

Downstream Products

• 104362-52-9 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-methylethenyl)-2-azetidinone 
• 93711-85-4 (2R)-2-[(2S,3S)-3-{(1R)-1-(t-butyldimethylsilyloxy)ethyl}-4-oxoazetidin-2-yl]propionic acid 
• 143139-22-4 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-methylethenyl)-2-azetidinone 
• 104362-57-4 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-hydroxymethylethenyl)-2-azetidinone 
• 104362-56-3 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-chloromethylethenyl)-2-azetidinone 
• 104362-99-4 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-<(R)-1-carboxyethyl>-2-azetidinone 
• 112057-69-9 Carbonic acid benzyl ester (R)-1-{(2R,3S)-2-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 
• 105557-93-5 Carbonic acid benzyl ester (R)-1-{(2R,3S)-2-[1-methyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-4-oxo-azetidin-3-yl}-ethyl ester 
• 143139-23-5 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-tert-butyldimethylsilyloxymethylethenyl)-2-azetidinone 
• 104362-83-6 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-<1-(2-tetrahydropyranyloxy)methylethenyl>-2-azetidinone 
• 104362-59-6 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-tert-butyldimethylsilyl-4-(1-tert-butyldimethylsilyloxymethylethenyl)-2-azetidinone 
• 104362-92-7 Carbonic acid benzyl ester (R)-1-[(2R,3S)-2-[1-methyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-4-oxo-1-(tetrahydro-pyran-2-yl)-azetidin-3-yl]-ethyl ester 
• 104362-82-5 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(2-tetrahydropyranyl)-4-<1-(2-tetrahydropyranyloxy)methylethenyl>-2-azetidinone 
• 104362-55-2 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-hydroxymethylethenyl)-2-azetidinone 

Relevant academic research and scientific papers

Synthetic studies of carbapenem and penem antibiotics. III. A synthesis of a key intermediate for 1β-methylcarbapenem

We synthesized useful intermediates 5 and 6 for 1β- and 1α-methylcarbapenems from 4-carboxy-3-[(R)-1-hydroxyethyl]-2-azetidinone 4 as a starting material by using stereoselective hydrogenation and hydroboration, respectively. A practical synthetic route from 4 to the (3S,4S)-4-[(R)-1-carboxyethyl]-3-[(R)-1-hydroxyethyl]-2-azetidinone derivative 1, a useful intermediate for the synthesis of 1β-methylcarbapenem antibiotics, was established.