112057-69-9

Upstream product

• 143139-23-5 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-tert-butyldimethylsilyloxymethylethenyl)-2-azetidinone 
• 86258-97-1 (3S,4S)-4-carboxy-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-2-azetidinone 
• 501-53-1 benzyl chloroformate 
• 104362-57-4 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-hydroxymethylethenyl)-2-azetidinone 
• 104362-56-3 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-chloromethylethenyl)-2-azetidinone 
• 104362-86-9 (3S,4S)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-(1-hydroxy-1-methylethyl)-2-azetidinone 
• 104362-85-8 (3S,4S)-1-(di-p-anisylmethyl)-3-<(R)-1-hydroxyethyl>-4-methoxycarbonyl-2-azetidinone 
• 104362-52-9 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-methylethenyl)-2-azetidinone 
• 112057-78-0 (3S,4R)-4-<(R)-1-(t-butyldimethylsilyloxymethyl)ethyl>-3-<(R)-1-hydroxyethyl>-2-azetidinone 
• 105318-33-0 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-(1-chloromethylethenyl)-1-(di-p-anisylmethyl)-2-azetidinone 
• 104380-26-9 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-1-(di-p-anisylmethyl)-4-(1-hydroxyl-1-methylethyl)-2-azetidinone 

Downstream Products

• 104362-98-3 (3S,4S)-3-<(R)-1-benzyloxycarbonyloxyethyl>-4-<(R)-1-hydroxymethylethyl>-2-azetidinone 

Relevant academic research and scientific papers

Synthetic studies of carbapenem and penem antibiotics. III. A synthesis of a key intermediate for 1β-methylcarbapenem

We synthesized useful intermediates 5 and 6 for 1β- and 1α-methylcarbapenems from 4-carboxy-3-[(R)-1-hydroxyethyl]-2-azetidinone 4 as a starting material by using stereoselective hydrogenation and hydroboration, respectively. A practical synthetic route from 4 to the (3S,4S)-4-[(R)-1-carboxyethyl]-3-[(R)-1-hydroxyethyl]-2-azetidinone derivative 1, a useful intermediate for the synthesis of 1β-methylcarbapenem antibiotics, was established.

Amino acid derivatives, and their production

An amino acid derivative of the formula: STR1 wherein R1 is a protective group for hydroxyl, which is useful as an intermediate for production of antimicrobial agent.