1043872-75-8

Upstream product

• 861335-99-1 3-benzyl-5-methyl oxindole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1290607-17-8 (R)-tert-butyl 3-((S)-1-acetamido-2-nitroethyl)-3-benzyl-5-methyl-2-oxoindoline-1-carboxylate 
• 1391859-19-0 tert-butyl 3-benzyl-3-(1,4-dioxo-1,4-diphenylbutan-2-yl)-5-methyl-2-oxoindoline-1-carboxylate 
• 1351305-97-9 (R)-ethyl 2-acetoxy-2-((R)-3-benzyl-5-methyl-2-oxoindolin-3-yl)acetate 
• 1229652-74-7 (S)-tert-butyl-3-benzyl-3-(hydroxymethyl)-5-methyl-2-oxoindoline-1-carboxylate 
• 1043872-90-7 C₃₃H₃₈N₂O₅ 

Relevant academic research and scientific papers

Polyfunctional Bis-Lewis-Acid-/Bis-Triazolium Catalysts for Stereoselective 1,4-Additions of 2-Oxindoles to Maleimides

Achieving enzyme-like catalytic activity and stereoselectivity without the typically high substrate specificity of enzymes is a challenge in the development of artificial catalysts for asymmetric synthesis. Polyfunctional catalysts are considered to be a promising tool for achieving excellent catalytic efficiency. A polyfunctional catalyst system was developed, which incorporates two Lewis acidic/Br?nsted basic cobalt centers in combination with triazolium moieties that are crucial for high reactivity and excellent stereoselectivity in the direct 1,4-addition of oxindoles to maleimides. The catalyst is assembled through click chemistry and is readily recyclable through precipitation by making use of its charges. Kinetic studies support a cooperative mode of action. Diastereodivergency is achievable with either Boc-protected or unprotected maleimide.