1043899-38-2Relevant academic research and scientific papers
Arylation of phe and tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water
Vilaro, Maria,Arsequell, Gemma,Valencia, Gregorio,Ballesteros, Alfredo,Barluenga, Jose
supporting information; experimental part, p. 3243 - 3245 (2009/05/27)
(Chemical Equation Presented) An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected iodopeptides is accomplished by using Suzuki-Miyaura cross-coupling processes. The method is compatible with the hydrophilic and thermolabile nature of biologically active peptides. Also of interest, the arylated tyrosine peptides can be accessed in one-pot mode starting from native peptides.
