10439-48-2

Basic information

• Product Name: 1,3-BIS(4-HYDROXYPHENOXY)PROPANE
• Synonyms: 4,4'-[1,3-Propanediylbis(oxy)]diphenol; 4,4'-[Propan-1,3-diylbis(oxy)]dibenzolol; 4,4'-[Propane-1,3-diylbis(oxy)]diphenol; phenol, 4,4'-[1,3-propanediylbis(oxy)]bis-
• CAS NO: 10439-48-2
• Molecular Formula: C₁₅H₁₆O₄
• Molecular Weight: 260.2851
• Mol File: 10439-48-2.mol

Chemical Properties

• Boiling Point: 470.599°C at 760 mmHg
• Flash Point: 238.41°C
• Density: 1.23g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 1,3-BIS(4-HYDROXYPHENOXY)PROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS(4-HYDROXYPHENOXY)PROPANE(10439-48-2)
• EPA Substance Registry System: 1,3-BIS(4-HYDROXYPHENOXY)PROPANE(10439-48-2)

Safety Data

• Hazardous Substances Data: 10439-48-2(Hazardous Substances Data)

Usage

Chemical compound

1,3-Bis(4-hydroxyphenoxy)propane

Usage

Building block in the production of epoxy resins

Applications

Adhesives, coatings, and composites

Molecular structure

Contains two hydroxyphenyl groups and a propane backbone

Properties

High chemical stability, thermal resistance, and mechanical strength

Importance

Component in the production of durable and high-performance materials

Ongoing research

Potential health risks and environmental impact

Controversy

Possible endocrine-disrupting effects and leaching from products

Upstream product

• 123-31-9 hydroquinone 
• 109-64-8 1,3-dibromo-propane 
• 103-16-2 4-Benzyloxyphenol 
• 86955-47-7 C₂₉H₂₈O₄ 

Downstream Products

• 1285718-53-7 C₄₉H₈₂N₂O₆ 
• 86955-29-5 (S)-1-(4-{3-[4-((S)-2-Hydroxy-3-isopropylamino-propoxy)-phenoxy]-propoxy}-phenoxy)-3-isopropylamino-propan-2-ol 
• 86955-53-5 (S,S)-1,1'-<1,3-propanediylbis(oxy)bis(1,4-phenylenoxy)>bis<3-<(1-methylethyl)(methylsulfonyl)amino>-2-propanol> 
• 3875-75-0 1,3-bis(4-methoxyphenoxy)propane 

Relevant articles and documents

Relationship between conformational flexibility and chelate cooperativity

A family of four biscarbamates (AA) and four bisphenols (DD) were synthesized, and H-bonding interactions between all AA?DD combinations were characterized using 1H NMR titrations in carbon tetrachloride. A chemical double mutant cycle analysis

β1-Selective Adrenoceptor Antagonists. 1. Synthesis and β-Adrenergic Blocking Activity of a Series of Binary (Aryloxy)propanolamines

A series of binary (aryloxy)propanolamines has been prepared and examined in vitro and in vivo for β-adrenoreceptor blocking activity.These symmetrical compounds consist of two (S)-(phenyloxy)propanolamine pharmacophores coupled through alkylenedioxy or poly(oxyethylenedioxy) linking units of varying lengths.Examples of such binary compounds linked through the 2,2', 3,3', and 4,4' positions in the aromatic rings of the pharmacophores have been prepared.In vitro and in vivo test data indicate that the 2,2' compounds tend to be selective β2-adrenergic blocking agents, the 4,4' binaries tend to be selective β1-blocking agents, and those compounds with 3,3' linkages exhibit intermediate selectivities.One of the 4,4'-linked binary compounds, 4s, exhibited potent, cardioselective β-blockade in vivo, which was of short duration and was accompanied by a prolonged tachycardia.