104392-50-9Relevant academic research and scientific papers
A facile anchoring of the bisphosphonate moiety into alcohols and phenols through copper carbenoid mediated O-H insertion reaction
Lecerclé, Delphine,Taran, Frédéric
, p. 1863 - 1868 (2007)
A straightforward procedure ensuring the anchoring of bisphosphonate moiety into alcohols or phenols is described. The method uses a bisphosphonate-metal- carbenoid O-H insertion reaction for which copper(II) triflate was found to be an efficient catalyst
Bisphosphonic acids and esters
-
, (2008/06/13)
The present invention relates to hitherto unknown compounds of the formula I STR1 in which R1 is a straight or branched, saturated or unsaturated aliphatic or alicyclic C1 -C10 hydrocarbon radical, an aryl or an aryl-C1 -C4 -alkyl radical, R1 if desired being unsubstituted or substituted with straight or branched C1 -C4 -alkyl, amino, C1 -C4 -alkamino, di-(C1 -C4 -alkyl)-amino, carboxy, C1 -C4 -alkoxycarbonyl, hydroxy, C1 -C4 -alkoxy, phenoxy, mercapto, C1 -C4 -alkylthio, phenylthio, halogen, trifluoromethyl; R2 stands for hydrogen, C1 -C8 -alkyl, aryl-C1 -C4 -alkyl or halogen; X is O or S, and n is an integer from 0 to 2; with the proviso that R2 cannot be hydrogen or methyl if n=O and R1 is methyl. The compounds of the invention are valuable in the human and veterinary practice.
