104408-24-4

Usage

Uses

Used in Pharmaceutical Industry:
3-Pyridinecarbonitrile,6-hydrazino-(9CI) is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the formation of diverse fused heterocyclic systems, which can exhibit a range of biological activities.
Used in Chemical Synthesis:
3-Pyridinecarbonitrile,6-hydrazino-(9CI) is used as a reactant for the preparation of fused 3-amino-1,2,4-triazoles. These fused triazoles are important building blocks in the development of new chemical entities with potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 27032-63-9 5-chloro-pyridin-2-yl hydrazine 
• 302-01-2 hydrazine 
• 33252-28-7 6-chloronicotinonitrile 

Downstream Products

• 664991-56-4 N-(5-cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-acetamide 
• 700806-96-8 6-[5-amino-3-(2-chloro-phenylamino)-[1,2,4]triazol-1-yl]-nicotinonitrile 
• 700807-07-4 6-[5-amino-3-(2-methoxy-4-morpholin-4-yl-phenylamino)-[1,2,4]triazol-1-yl]-nicotinonitrile 
• 425702-03-0 3-oxo-2H,3H-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile 

Relevant academic research and scientific papers

SUBSTITUTED SULFONYL HYDRAZIDES AS INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY

The present invention relates to substituted sulfonyl hydrazides that have the ability to inhibit lysine biosynthesis via the diaminopimelate pathway in certain organisms. As a result of this activity these compounds can be used in applications where inhibition of lysine biosynthesis is useful applications of this type include the use of the compound as herbicides and/or anti- bacterial agents.

Keeping it small, polar, and non-flat: diversely functionalized building blocks containing the privileged 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]- and [1,5-a]pyridine cores

Six sets of functionalized building blocks based on 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine as well as 5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine cores have been prepared. These compounds are non-flat, bicyclic heterocycles that are likely to find utility as privileged motifs for lead-like compound design. One set of building blocks, (5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-6-ylmethyl)amines, proved useful as a scaffold for developing compounds that stimulate glucagon-like peptide-1 (GLP-1) secretion and are novel anti-diabetes drug leads.

NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present invention relates to compounds of general formula I, wherein R1, LP, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

SUBSTITUTED PIPERIDINES AS GPR119 MODULATORS FOR THE TREATMENT OF METABOLIC DISORDERS

The present invention relates to compounds of general formula (I), wherein R1, Lp, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES

The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.

SUBSTITUTED DIPYRIDYL-DIHYDROPYRAZOLONES AND USE THEREOF

The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

cMET INHIBITORS

Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of GPR119 for the treatment or prevention of metabolic, cardiovascular, and metabolic diseases.

SUBSTITUTED PYRROLOPYRIDINES

There are provided novel compounds of formula (I) wherein R1, R2 and R3 are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.