27032-63-9

Basic information

• Product Name: (5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE
• Synonyms: 5-CHLORO-2-HYDRAZINOPYRIDINE;(5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE;(5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE 5193-03-3
• CAS NO: 27032-63-9
• Molecular Formula: C₅H₆ClN₃
• Molecular Weight: 143.57
• Mol File: 27032-63-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 127-128
• Boiling Point: 288.012 °C at 760 mmHg
• Flash Point: 127.985 °C
• Appearance: /
• Density: 1.418 g/cm³
• Vapor Pressure: 288oC at 760mmHg
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.00±0.70(Predicted)
• CAS DataBase Reference: (5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE(27032-63-9)
• EPA Substance Registry System: (5-CHLORO-PYRIDIN-2-YL)-HYDRAZINE(27032-63-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 27032-63-9(Hazardous Substances Data)

Usage

General Description

(5-Chloro-pyridin-2-yl)-hydrazine is a chemical compound with the molecular formula C5H5ClN4. It is a hydrazine derivative with a chloro-pyridine functional group attached to the hydrazine molecule. This chemical has potential applications in pharmaceuticals, agrochemicals, and materials science. It may be used as a building block in the synthesis of various organic compounds and may have biological activity that makes it useful in drug discovery and development. Additionally, it may have uses in the field of materials science for the preparation of specialized polymers or materials. However, like many chemical compounds, it should be handled with caution and in accordance with proper safety protocols.

InChI:InChI=1S/C5H6ClN3/c6-4-1-2-5(9-7)8-3-4/h1-3H,7H2,(H,8,9)

Upstream product

• 16110-09-1 2,5 dichloropyridine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 1072-98-6 5-chloro-2-pyridylamine 

Downstream Products

• 104408-24-4 5-cyano-pyridin-2-ylhydrazine 
• 27032-65-1 cyclohexanone (5-chloropyridin-2-yl)hydrazone 
• 1072-98-6 5-chloro-2-pyridylamine 
• 1394062-37-3 3-chloro-6-methyl-6,7,8,9-tetrahydro-5H-pyrido-[3',4':4,5]pyrrolo[2,3-b]pyridine 
• 1159831-32-9 C₇H₄ClN₃O₂ 

Relevant articles and documents

Synthesis of 5-chloro-7-azaindoles by Fischer reaction

[Figure not available: see fulltext.] A simple and effective method on the basis of Fischer reaction in polyphosphoric acid is proposed for the synthesis of previously unknown heterocyclic structures that contain the 5-chloro-1H-pyrrolo[2,3-b]pyridine system. This method can be used for the synthesis of 3-substituted and 2,3-disubstituted 5-chloro-7-azaindoles with alkyl and aryl substituents.

CYANINE DYES AND THEIR CONJUGATES

Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared spectral range. The cyanine compounds of Formula (I), are presented: wherein Q is a portion of a polymethine bridge selected from the group consisting (Formula (X)). Also included are bioconjugates of the compounds of Formula (I), methods of labeling biomolecules with the compounds, and methods of imaging.

4-(PYRIDIN-3-YL)-2-(PYRIDIN-2-YL)-1,2-DIHYDRO-3H-PYRAZOL-3-ONE DERIVATIVES AS SPECIFIC HIF-PROLYL-4-HYDROXYLASE INHIBITORS FOR TREATING CARDIOVASCULAR AND HAEMATOLOGICAL DISEASES

The object of the invention is to provide new compounds which can be used for the treatment of diseases, in particular cardiovascular and haematological diseases. The present invention describes compounds which act as specific HIF-prolyl-4-hydroxylase inhibitors and which, because of this specific in vivo action mechanism, induce HIF target genes, such as erythropoietin, and the thus produced biological processes, such as erythropoiesis, after parenteral or oral administration. The present invention relates to compounds having the general formula (I), in which A stands for CH or N, R1 stands for a substituent selected from the group formed by (C1-C6)-alkyl, trifluoromethyl, halogen, cyano, nitro, hydroxy, (C1-C6)-alkoxy, amino, (C1-C6)-alkoxycarbonyl, hydroxycarbonyl and C(=O)-NH-R4; R2 stands for a substituent selected from the group formed by halogen, cyano, nitro, (C1-C6)-alkyl, trifluoromethyl, hydroxy, (C1-C6)-alkoxy, trifluoromethoxy, amino, hydroxycarbonyl and C(=O)-NH-R8; m equals 0, 1 or 2; n equals 0, 1, 2 or 3, it being possible for these meanings to be the same or different when R1 or R2 occurs multiple times; and R3 stands for hydrogen, (C1-C6)-alkyl or (C3-C7)-cycloalkyl. The invention also relates to the salts, solvates, and salt solvates of these compounds.