1044152-65-9Relevant academic research and scientific papers
Three-component condensation of α-nitroacetophenone, aromatic aldehydes, and methylurea
Sedova,Krivopalov,Shkurko
, p. 1184 - 1189 (2008/09/19)
The three-component condensation of aromatic aldehydes, methylurea, and α-nitroacetophenone affords both N(1)-and N(3)-methyl-substituted 4,6-diaryl-5-nitro-3,4-dihydropyrimidin-2(1H)-ones depending on the structure of aldehyde. Intermediate 4,6-diaryl-4-hydroxy-3-methyl-5-nitrohexahydropyrimidin- 2-ones and trisubstituted urea, which is the transformation product of the 4-hydroxy-3-methyl derivative in an acidic medium (retro-Henry reaction), were identified in the reaction mixtures.
