10442-03-2

Basic information

• Product Name: 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE
• Synonyms: CHEMPACIFIC 36184;4-(2-PROPYNYL)THIOMORPHOLINE 1,1-DIOXIDE;4-PROP-2-YNYL-1LAMBDA6,4-THIAZINANE-1,1-DIONE;4-(Prop-2-ynyl)thiomorpholine 1,1-dioxide;4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE;4-(Prop-2-yn-1-yl)thiomorpholine 1,1-dioxide;1,1-Dioxido-4-(prop-2-yn-1-yl)thiomorpholine, 1,1-Dioxido-4-(prop-2-yn-1-yl)-1,4-thiazinane;thiomorpholine, 4-(2-propyn-1-yl)-, 1,1-dioxide
• CAS NO: 10442-03-2
• Molecular Formula: C₇H₁₁NO₂S
• Molecular Weight: 173.23
• Product Categories: Acetylenes;Functionalized Acetylenes
• Mol File: 10442-03-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 114 °C
• Boiling Point: 333.7°Cat760mmHg
• Flash Point: 155.6°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 0.000134mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: 2-8°C
• Solubility: almost transparency in hot Methanol
• PKA: 3.80±0.20(Predicted)
• CAS DataBase Reference: 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE(10442-03-2)
• EPA Substance Registry System: 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE(10442-03-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 10442-03-2(Hazardous Substances Data)

Usage

General Description

4-Propargylthiomorpholine 1,1-dioxide is a chemical compound with the molecular formula C5H7NOS. It is a heterocyclic organic compound that contains a morpholine ring with a propargylthio group attached to it. 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE is used as a stabilizer in the synthesis of nitroxyl radicals and is also reported to have potential biological activity as a free radical scavenger. Additionally, it has been studied for its potential use in the treatment of diseases such as heart failure and ischemia-reperfusion injury due to its ability to protect against oxidative damage and inflammation. Overall, 4-propargylthiomorpholine 1,1-dioxide is a versatile compound with potential applications in both chemical synthesis and medicinal research.

InChI:InChI=1/C7H11NO2S/c1-2-3-8-4-6-11(9,10)7-5-8/h1H,3-7H2

Upstream product

• 162936-38-1 4-(prop-2-yn-1-yl)thiomorpholine 
• 77-77-0 Divinyl sulfone 
• 2450-71-7 Propargylamine 

Downstream Products

• 1092557-11-3 3-(4-methoxyphenyl)-4-(S,S-dioxothiomorpholinomethyl)isoxazole 
• 1192143-40-0 C₁₃H₁₄ClNO₂S 
• 1192143-29-5 C₁₆H₁₉NO₄S 
• 1192143-19-3 C₂₀H₁₉NO₃S 
• 1393746-05-8 C₂₅H₃₃F₂N₅O₁₁S 
• 1070671-77-0 methyl 2-phenyl-2-(4-(3-(1,1-dioxidothiomorpholin-4-yl)prop-1-ynyl)phenyl)acetate 
• 458524-70-4 N-(4-chlorobenzyl)-8-[3-(1,1-dioxidothiomorpholin-4-yl)prop-1-ynyl]-1-methyl-6-(morpholin-4-ylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide 

Relevant articles and documents

One-pot synthesis of sulfonyl-1H-1,2,3-triazolyl-thiomorpholine 1,1-dioxide derivatives and evaluation of their biological activity

A one-pot procedure for the synthesis of novel 1,2,3-triazole derivatives (5a–5l) in good yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide through the in situ generated sulfonyl azides was developed. The structures of the newly synthesized compounds were confirmed by 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were screened for in?vitro antibacterial activity and free radical scavenging activity in terms of hydrogen donating or radical scavenging ability by the DPPH method. Among all, the compound N-(4-((4-((1,1-dioxidothiomorpholino) methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)phenyl) acetamide (5l) was found to exhibit potent activity as compared to the standard drugs.