10442-03-2

Usage

General Description

4-Propargylthiomorpholine 1,1-dioxide is a chemical compound with the molecular formula C5H7NOS. It is a heterocyclic organic compound that contains a morpholine ring with a propargylthio group attached to it. 4-PROPARGYLTHIOMORPHOLINE 1,1-DIOXIDE is used as a stabilizer in the synthesis of nitroxyl radicals and is also reported to have potential biological activity as a free radical scavenger. Additionally, it has been studied for its potential use in the treatment of diseases such as heart failure and ischemia-reperfusion injury due to its ability to protect against oxidative damage and inflammation. Overall, 4-propargylthiomorpholine 1,1-dioxide is a versatile compound with potential applications in both chemical synthesis and medicinal research.

InChI:InChI=1/C7H11NO2S/c1-2-3-8-4-6-11(9,10)7-5-8/h1H,3-7H2

Upstream product

• 77-77-0 Divinyl sulfone 
• 2450-71-7 Propargylamine 
• 162936-38-1 4-(prop-2-yn-1-yl)thiomorpholine 

Downstream Products

• 1092557-11-3 3-(4-methoxyphenyl)-4-(S,S-dioxothiomorpholinomethyl)isoxazole 
• 1192143-40-0 C₁₃H₁₄ClNO₂S 
• 1192143-29-5 C₁₆H₁₉NO₄S 
• 1192143-19-3 C₂₀H₁₉NO₃S 

Relevant academic research and scientific papers

One-pot synthesis of sulfonyl-1H-1,2,3-triazolyl-thiomorpholine 1,1-dioxide derivatives and evaluation of their biological activity

A one-pot procedure for the synthesis of novel 1,2,3-triazole derivatives (5a–5l) in good yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide through the in situ generated sulfonyl azides was developed. The structures of the newly synthesized compounds were confirmed by 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were screened for in?vitro antibacterial activity and free radical scavenging activity in terms of hydrogen donating or radical scavenging ability by the DPPH method. Among all, the compound N-(4-((4-((1,1-dioxidothiomorpholino) methyl)-1H-1,2,3-triazol-1-yl)sulfonyl)phenyl) acetamide (5l) was found to exhibit potent activity as compared to the standard drugs.

Dioxane quinazoline and dioxane quinazoline type compound, and preparation method and application thereof

The invention relates to a dioxane quinazoline and dioxane quinazoline type compound having a formula (I) as described in the specification or a pharmaceutically acceptable salt thereof. The inventionalso provides preparation of the compound having the formula (I) and the pharmaceutically acceptable salt and application of the compound and the pharmaceutically acceptable salt as a medicine. The medicine is used as a tyrosine kinase (such as VEGFR-2, c-MET and RET) inhibitor for treating diseases relevant to tyrosine kinases.