1044200-52-3Relevant academic research and scientific papers
Performance of C1-symmetric chiral ammonium betaines as catalysts for the enantioselective Mannich-type reaction of α- nitrocarboxylates
Uraguchi, Daisuke,Koshimoto, Kyohei,Sanada, Chisato,Ooi, Takashi
scheme or table, p. 1189 - 1190 (2010/10/20)
The catalytic performance of C1-symmetric chiral ammonium betaines in the enantioselective direct Mannich-type reaction of α-nitrocarboxylates with N-Boc imines has been investigated. The most effective catalyst structure has been identified; this provides a reliable synthetic route to a variety of enantiomerically enriched α- tetrasubstituted α,β-diamino acid derivatives.
Chiral ammonium betaines: A bifunctional organic base catalyst for asymmetric mannich-type reaction of α-nitrocarboxylates
Uraguchi, Daisuke,Koshimoto, Kyohei,Ooi, Takashi
supporting information; scheme or table, p. 10878 - 10879 (2009/02/05)
A chiral ammonium betaine, an intramolecular ion-pairing quaternary ammonium aryloxide 3, has been designed and its vast potential as an enantioselective organic base catalyst has been successfully demonstrated in the highly enantioselective direct Mannich-type reaction of α-substituted α-nitrocarboxylates 2 with various N-Boc imines 1. The present study provides a conceptually new approach toward the design of bifunctional, chiral quaternary ammonium salts and their utilizations as a homogeneous organic molecular catalyst. Copyright
