1044222-31-2

Upstream product

• 16413-86-8 2,2,2-trifluoroacetaldehyde-d 
• 56613-80-0 D-2-phenylglycinol 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 

Downstream Products

• 461440-76-6 (2R)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-propionitrile 
• 461440-79-9 (3R)-4,4,4-trifluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-1-phenylbutanone 
• 1026021-03-3 (2R,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine 
• 1026021-02-2 (2S,4R)-2-trifluoromethyl-4-phenyl-3-propenoyloxazolidine 
• 1044222-25-4 (4R)-(-)-5,5,5-trifluoro-4-[(1R)-2-hydroxy-1-phenylethylamino]pentan-2-one 
• 1044222-26-5 (2R)-2-phenyl-2-[(2R)-1,1,1-trifluoro-3-(2-methyl-1,3-dioxan-2-yl)propan-2-ylamino]ethanol 
• 1428339-72-3 C₁₀H₁₀F₃NO*C₇H₈O₃S 
• 203176-56-1 (2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine 
• 1428339-78-9 (2S,4R)-3-[(R)-2-fluorohexanoyl]-4-phenyl-2-trifluoromethyloxazolidine 
• 1428339-76-7 (2S,4R)-3-[(2R)-2-fluoro-2-phenylacetyl]-4-phenyl-2-trifluoromethyloxazolidine 
• 1428339-74-5 (2S,4R)-hexanoyl-4-phenyl-2-trifluoromethyloxazolidine 
• 1428339-73-4 (2S,4R)-4-phenyl-3-phenylacetyl-2-trifluoromethyloxazolidine 
• 461440-80-2 ethyl (3R)-4,4,4-trifluoro-3-((1R)-2-hydroxy-1-phenylethylamino)butanoate 

Relevant academic research and scientific papers

DEUTERATED ANALOGS OF AN ORGANIC COMPOUND

Provided are deuterated analogs of a compound and methods of using such deuterated analogs for treating a brain tumor in a patient in need thereof; the treatment comprising administering to the patient a deuterated compound described herein. The deuterated compound may be administered in combination with radiation therapy and/or an additional therapeutic agent.

Lewis acid activation of chiral 2-trifluoromethyl-1,3-oxazolidines. Application to the stereoselective synthesis of trifluoromethylated amines, α- and β-amino acids

The reaction of chiral 2-trifluoromethyl-1,3-oxazolidines with various silylated nucleophiles under Lewis acid activation provides a stereoselective route to functionalized α-trifluoromethylamines. This methodology was successfully applied to the diastereoselective synthesis of trifluoromethylated homoallylic and propargylic amines, trifluoromethylated α-amino nitrile, β-aminoketone and β-aminoester. The α-amino nitrile and the β-amino ester were converted into (+)-3,3,3-trifluoroalanine and (+)-4,4,4-trifluoro-3-aminobutanoic acid in a one-step procedure.