461440-80-2

Upstream product

• 881424-14-2 (4R)-4-trifluoromethyl-1-((1R)-2-hydroxy-1-phenylethyl)azetidin-2-one 
• 64-17-5 ethanol 
• 56613-80-0 D-2-phenylglycinol 
• 1044222-31-2 (4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine 
• 18295-66-4 1-ethoxy-1-(trimethylsiloxy)ethene 

Downstream Products

• 881424-25-5 (3R)-4,4,4-trifluoro-3-((1R)-2-hydroxy-1-phenylethylamino)butan-1-ol 
• 461440-79-9 (3R)-4,4,4-trifluoro-3-((1R)-2-hydroxy-1-phenylethylamino)-1-phenylbutanone 
• 881424-16-4 (5R)-6,6,6-trifluoro-5-((1R)-2-hydroxy-1-phenylethylamino)-2,2-dimethylhexan-3-one 

Relevant academic research and scientific papers

Convenient asymmetric synthesis of β-trifluoromethyl-β-amino acid, β-amino ketones, and γ-amino alcohols via Reformatsky and Mannich-type reactions from 2-trifluoromethyl-1,3-oxazolidines

The stereoselective syntheses of β-trifluoromethyl-β-amino ester, β lactams, and β-amino ketones starting from an oxazolidine derived from trifluoroacetaldehyde hemiacetal and (R)-phenylglycinol are reported. The Mannich-type reaction involving a chiral f

Lewis acid activation of chiral 2-trifluoromethyl-1,3-oxazolidines. Application to the stereoselective synthesis of trifluoromethylated amines, α- and β-amino acids

The reaction of chiral 2-trifluoromethyl-1,3-oxazolidines with various silylated nucleophiles under Lewis acid activation provides a stereoselective route to functionalized α-trifluoromethylamines. This methodology was successfully applied to the diastereoselective synthesis of trifluoromethylated homoallylic and propargylic amines, trifluoromethylated α-amino nitrile, β-aminoketone and β-aminoester. The α-amino nitrile and the β-amino ester were converted into (+)-3,3,3-trifluoroalanine and (+)-4,4,4-trifluoro-3-aminobutanoic acid in a one-step procedure.