1044284-89-0Relevant academic research and scientific papers
Native Chemical Ligation-Photodesulfurization in Flow
Chisholm, Timothy S.,Clayton, Daniel,Dowman, Luke J.,Sayers, Jessica,Payne, Richard J.
, p. 9020 - 9024 (2018)
Native chemical ligation (NCL) combined with desulfurization chemistry has revolutionized the way in which large polypeptides and proteins are accessed by chemical synthesis. Herein, we outline the use of flow chemistry for the ligation-based assembly of polypeptides. We also describe the development of a novel photodesulfurization transformation that, when coupled with flow NCL, enables efficient access to native polypeptides on time scales up to 2 orders of magnitude faster than current batch NCL-desulfurization methods. The power of the new ligation-photodesulfurization flow platform is showcased through the rapid synthesis of the 36 residue clinically approved HIV entry inhibitor enfuvirtide and the peptide diagnostic agent somatorelin.
NEW SYNTHETIC METHODS USING NATIVE CHEMICAL LIGATION IN FLOW
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Page/Page column 11; 13; 48; 49; 62, (2019/12/15)
The disclosure relates to the synthesis of amide containing compounds in flow. In particular, the disclosure relates to the synthesis of polypeptides via native chemical ligation in flow. The disclosure also relates to selective desulfurization or deselen
