1044285-01-9Relevant academic research and scientific papers
Cysteine-free peptide and glycopeptide ligation by direct aminolysis
Payne, Richard J.,Ficht, Simon,Greenberg, William A.,Wong, Chi-Huey
supporting information; scheme or table, p. 4411 - 4415 (2009/02/08)
(Chemical Equation Presented) Left to their own devices in a mixed-solvent system, peptides undergo efficient aminolysis with peptide thioesters (see scheme). This ligation method, which does not require coupling reagents, auxiliaries, or an N-terminal cysteine residue, is suitable for a variety of amino acids at the ligation junction. Its effectiveness was demonstrated by the synthesis of a 6.9-kDa section of the cancer-associated MUC1 tandem repeat.
