1044507-47-2Relevant academic research and scientific papers
PROSTAGLANDIN EP4 RECEPTOR ANTAGONIST COMPOUNDS
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Page/Page column 65-66, (2021/04/17)
The disclosures herein relate to novel compounds of formula (1): (1) and salts thereof, wherein A, X, R1, R2, R3, R4, R10 and R11 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of disorders associated with EP4 receptors.
Preparation of aryloxetanes and arylazetidines by use of an alkyl-aryl suzuki coupling
Duncton, Matthew A. J.,Estiarte, M. Angels,Tan, Darlene,Kaub, Carl,O'Mahony, Donogh J. R.,Johnson, Russell J.,Cox, Matthew,Edwards, William T.,Wan, Min,Kincaid, John,Kelly, Michael G.
experimental part, p. 3259 - 3262 (2009/05/07)
(Chemical Equation Presented) The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to installing these two modules into aromatic systems, using a nickel-mediated alkyl-aryl Suzuki coupling, is presented.
