1044518-06-0Relevant articles and documents
Chiral ammonium betaines: A bifunctional organic base catalyst for asymmetric mannich-type reaction of α-nitrocarboxylates
Uraguchi, Daisuke,Koshimoto, Kyohei,Ooi, Takashi
, p. 10878 - 10879 (2008)
A chiral ammonium betaine, an intramolecular ion-pairing quaternary ammonium aryloxide 3, has been designed and its vast potential as an enantioselective organic base catalyst has been successfully demonstrated in the highly enantioselective direct Mannich-type reaction of α-substituted α-nitrocarboxylates 2 with various N-Boc imines 1. The present study provides a conceptually new approach toward the design of bifunctional, chiral quaternary ammonium salts and their utilizations as a homogeneous organic molecular catalyst. Copyright