1044548-98-2

Upstream product

• 1445-69-8 2,3-dihydrophthalazine-1,4-dione 
• 100-52-7 benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 136918-14-4 phthalimide 
• 85-44-9 phthalic anhydride 

Relevant academic research and scientific papers

One-pot four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10- dione derivatives

The synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by NiCl2-catalyzed novel one-pot four-component condensation reaction of phthalimide, hydrazine, malononitrile (or ethyl cyanoacetate), and aromatic aldehydes was reported. This work provides a simple, efficient, and eco-friendly method for the construction of pyrazolo[1,2-b]phalazine-5,10-dione derivatives.

Sio2:mgmno3: An efficient heterogeneous catalyst for one pot synthesis of 1h-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

The present study deals with hydrothermal synthesis of SiO2 composite MgMnO3 catalyst. The obtained polycrystalline product was analyzed by using physical investigative techniques including XRD, SEM, EDAX, TEM, SAED and BET surface area. The product corresponded to average particle size of 100 nm by TEM images. The BET surface area was found 234.38 cm2/g for SiO2 composite MgMnO3 catalyst which indicates a good catalytic property. The synthesized catalyst was applied for the synthesis of 1H-pyrazolo[1,2-b]- phthalazine-5,10-dione in presence of ethanol as a solvent at 80°C. The current procedure and catalyst offers the gains of clean reaction, short reaction time, high yield, easy purification and financial availability of the catalyst.

Method of using ionic liquid to catalytically prepare pyrazolo[1,2-b]phthalazinone derivative

The invention discloses a method of using an ionic liquid to catalytically prepare pyrazolo[1,2-b]phthalazinone derivative. The method comprises: adding an aldehyde derivative shown as formula I, a compound shown as formula II, phthalylhydrazine, and an ionic liquid catalyst into a solvent, stirring at 0-80 DEG C in the nitrogen atmosphere for 1-15 h to obtain a reacted liquid; the reacted liquidis post-treated to obtain pyrazolo[1,2-b]phthalazinone derivative shown as formula III. The method herein has mild reaction conditions, convenient to operate, good in reaction selectivity, short in reaction time, good in separating and purifying convenience and good in yield, and its substituent group are easy to extend; ionic liquid catalysis is utilized, so that the method has the advantages ofgood dissolution, zero pollution, good environmental friendliness, catalyst reuse and the like, and is a promising synthetic method.

Efficient and convenient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline

An efficient, four-component, one-pot condensation reaction of phthalimide or phthalic anhydride, aromatic aldehydes, and ethyl cyanoacetate for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives mediated by L-proline in excellent yields is reported.

Synthesis of a diversified combinatorial library of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives applying sustainable carbon-based solid acid catalyst involving a domino four-component reaction

A SO3H-bearing carbonaceous solid catalyst has been synthesized through sulfonation followed by the hydrothermal carbonization method from renewable resource polyethylene glycol. The biodegradable catalyst was characterized by XRD, TEM, FT-IR, and energy dispersive X-ray. The surface area and pore diameter of the catalyst were determined by a nitrogen adsorption-desorption isotherm experiment. A highly efficient multicomponent heteroannulation protocol for the synthesis of a library of 1H-pyrazolo[1,2-b] phthalazine-5,10-dione derivatives has been developed by applying the solid acid catalyst. This synthesis was established to follow the group-assistant- purification chemistry process avoiding traditional chromatography. The aqueous reaction medium, easy recovery of the catalyst, and high yield of the products make the protocol attractive, sustainable, and economic. This work may not only lead to environmentally benign systems, but also will provide a new aspect of organic chemistry in water.

A rapid and an efficient route to the one-pot, multicomponent synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione ring systems

CAN is found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives via one-pot coupling reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in PEG as solvent. The major attributes of this synthetic protocol are the use of nontoxic, inexpensive, and readily available catalyst, mild conditions, easy work up, improved yields, and the PEG 400 as solvent that is environmentally benign as well as recyclable.

Post synthesis alumination of KIT-6 materials with Ia3d symmetry and their catalytic efficiency towards multicomponent synthesis of 1H-pyrazolo[1,2-] phthalazine-5,10-dione carbonitriles and carboxylates

Alumination of Si-KIT-6 materials with ordered three-dimensional (3D) structure were prepared by post-synthesis method with various Si/Al ratios. The catalysts were characterized by X-ray diffraction analysis (XRD), N2 porosimetry and FT-IR spectra. The presence of framework and extra framework aluminium was predicted by Aluminium MAS NMR. The strength of the acid sites of the catalysts was studied by NH3-TPD acidity measurements. The morphology of mesoporous materials was studied by SEM and TEM observation. The metal content of the samples was investigated by ICP-OES. The prepared solid acid catalysts were applied for the multi-component synthesis of 1H-pyrazolo[1,2-]phthalazine-5,10-diones from the reaction of phthalhydrazide, malononitrile/ethylcyano acetate and aromatic aldehyde in ethanol under liquid phase conditions. Activities of the catalysts follow the order: Al-KIT-6 (33) > Al-KIT-6 (56) > Al-KIT-6 (81) > Al-KIT-6 (110) > Nafion-H > Amberlyst-15 HM (12) > Hβ (8) > HY (4). The effects of reaction conditions and different catalysts have been studied. Various advantages associated with these protocols include effective catalysis, simple work-up procedure, short reaction times, high product yields, easy recovery and reusability of the catalysts.

A highly efficient green synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10- dione derivatives and their photophysical studies

A task-specific ionic liquid, [Bmim]OH, has been used for an efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot cyclocondensation reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate under microwave irradiation. The advantages of this method include the use of green catalyst, no organic solvent, easy work-up and excellent yields. The photophysical properties for some 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives have been investigated for the first time.

Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones

Triethylamine was found to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in ethanol under ultrasonic irradiation. The advantages of this method are the use of an inexpensive and readily available catalyst, easy workup, improved yields, and the use of ethanol as a solvent that is considered to be relatively environmentally benign.

An efficient one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives

An efficient, three-component, one-pot condensation reaction between phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives in excellent yields is reported. Ge