1044589-82-3

Usage

Uses

Used in Pharmaceutical Industry:
7-Deaza-2'-C-ethynyladenosine is used as an antiviral agent for inhibiting the proliferation of EV71, a major causative agent of Hand-Foot-Mouth Disease. Its unique structure allows it to effectively target and suppress the replication of this virus, offering a potential therapeutic solution for controlling the disease.

Upstream product

• 108008-66-8 methyl 3,5-di-O-(4-chlorobenzyl)-α-D-ribofuranoside 
• 532-20-7 D-Ribose 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 1044589-94-7 (2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-4-((2,4-dichlorobenzyl)oxy)-5-(((2,4-dichlorobenzyl)oxy)methyl)-3-ethynyltetrahydrofuran-3-ol 
• 1044590-06-8 (2R,3R,4R,5R)-2-(4-chloro-pyrrolo[2,3-d]pyrimidin-7-yl)-4-(4-methylbenzoyloxy)-5-(4-methylbenzoyloxymethyl)-3-ethynyl-tetrahydrofuran-3-ol 
• 1044589-93-6 (3R,4R,5R)-5-(2,4-dichlorobenzyloxymethyl)-4-(2,4-dichlorobenzyloxy)-3-ethynyl-2-methoxy-tetrahydrofuran-3-ol 
• 1044590-05-7 1,2-anhydro-2-C-ethynyl-3,5-bis(4-methylbenzoyl)-α-D-ribofuranose 
• 636581-81-2 3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-ribofuranose 
• 636581-82-3 3,5-bis-O-(2,4-dichlorobenzyl)-1-O-methyl-α-D-erythro-pentofuranos-2-ulose 
• 1207518-58-8 (2R,3R,4R,5R)-2-(4-(isoindole-1,3-dione-2-yl)-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-hydroxymethyl-tetrahydrofuran-3,4-diol 
• 1044589-83-4 (2R,3R,4R,5R)-2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3-ethynyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 

Relevant academic research and scientific papers

2'-ethynyl adenosine phosphamide derivative as well as preparation method and application thereof

The invention relates to a compound as shown in a formula 2, an optical isomer, a raceme or a pharmaceutically acceptable salt thereof, and also relates to a pharmaceutical composition containing the compound, a method for preparing the compound and application of the compound in resisting enteroviruses.

NEW ANTIVIRAL MODIFIED NUCLEOSIDES

This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections.

NEW ANTIVIRAL MODIFIED NUCLEOSIDES

This invention relates to novel compounds that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections. wherein: X is CH or CR6; R1 is halogen, NR7R8 or OR9; R2 is H, halogen, or NR7R8; R3 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl or heteroaryl, each of which is optionally substituted with one or more substituents; R4 is H, acyl or an amino acid ester; R5 is H, acyl or an amino acid ester; R6 is alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, halogen, cyano, nitro, hydroxy, alkoxy, alkylthio, amino, alkylamino, carboxy, carboxamide or alkyloxycarbonyl, each of which is optionally substituted with one or more substituents; R7 and R8 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, amino, alkylamino, arylamino, hydroxy, alkoxy, arylcarbonyl and alkylcarbonyl, each of which is optionally substituted with one or more substituents; and R3 is H, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heterocycloalkyl, heteroaryl, alkylcarbonyl or arylcarbonyl, each of which is optionally substituted with one or more substituents;

NOVEL NUCLEOSIDE ANALOGS FOR TREATMENT OF VIRAL INFECTIONS

This invention relates to novel nucleoside compounds of formula (I) that have various medicinal applications, e.g. for the treatment and/or prevention of viral infections.