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Usage

Uses

Used in Flavorings and Perfumes:
4-METHOXY-2-(1-PHENYL-ETHYL)-PHENOL is used as a flavoring agent for its strong, spicy aroma, and as a component in perfumes due to its distinctive scent.
Used in Traditional Medicine:
In traditional medicine, 4-METHOXY-2-(1-PHENYL-ETHYL)-PHENOL is used as an analgesic and anti-inflammatory agent, leveraging its natural pain-relieving and inflammation-reducing properties.
Used in Dentistry:
4-METHOXY-2-(1-PHENYL-ETHYL)-PHENOL is used as a local antiseptic and anesthetic in dentistry, thanks to its ability to kill bacteria and numb the area, making dental procedures more comfortable for patients.
Used in Industrial Applications:
In various industries, 4-METHOXY-2-(1-PHENYL-ETHYL)-PHENOL is used for its antibacterial, antifungal, and antioxidant properties, contributing to the preservation and enhancement of products in areas such as food, cosmetics, and pharmaceuticals.
Used in Pharmaceutical Applications:
4-METHOXY-2-(1-PHENYL-ETHYL)-PHENOL is utilized in the development of pharmaceutical products due to its therapeutic potential in treating various conditions, including its analgesic, anti-inflammatory, and antimicrobial effects.

Upstream product

• 150-76-5 4-methoxy-phenol 
• 100-42-5 styrene 
• 93-92-5 1-phenylethyl acetate 
• 98-85-1 1-Phenylethanol 

Relevant academic research and scientific papers

HBF4- and AgBF4-Catalyzed ortho-Alkylation of Diarylamines and Phenols

A silver-tetrafluoroborate- or HBF4-catalyzed ortho-alkylation reaction of phenols and diarylamines with styrenes has been explored. A broad substrate scope is presented as well as mechanistic experiments and discussion.

Hydroarylation of styrenes with electron-rich arenes over acidic ion-exchange resins

A series of acidic cation-exchange resins were used for the hydroarylation of resorcinol with styrene, in which resin D072 exhibited the excellent catalytic performance in this reaction with 99% conversion of styrene and 90% selectivity of 4-(1-phenylethyl)resorcinol. It was applied to the hydroarylation of various electron-rich arenes with styrenes, and the hydroarylated products were quantitatively obtained. This catalyst could be used for four consecutive runs with slight decrease in activity. The hydroarylation of resorcinol with styrene over resin D072 in a fixed bed was completed effectively with 94% selectivity and 99% conversion, and this green continuous process is potentially applicable to large-scale productions.

3D Nanoporous FeAl-KIT-5 with a cage type pore structure: A highly efficient and stable catalyst for hydroarylation of styrene and arylacetylenes

A novel bimetallic nanoporous FeAl-KIT-5 catalyst with a cage type porous structure and a high surface area has been prepared for the hydroarylation of styrene and arylacetylenes to afford 1,1-diarylalkanes and 1,1-diarylalkenes, respectively. The catalyst was found to be highly active, and selective, affording a high yield of substituted alkanes and alkenes. The catalyst also showed much higher activity as compared to those of other nanoporous catalysts such as AlSBA-15, AlKIT-5, and FeKIT-5, and can be reused several times without much loss of its activity.

Dehydrative C-H alkylation and alkenylation of phenols with alcohols: Expedient synthesis for substituted phenols and benzofurans

A well-defined cationic Ru-H complex catalyzes the dehydrative C-H alkylation reaction of phenols with alcohols to form ortho-substituted phenol products. Benzofuran derivatives are efficiently synthesized from the dehydrative C-H alkenylation and annulation reaction of phenols with 1,2-diols. The catalytic C-H coupling method employs cheaply available phenols and alcohols, exhibits a broad substrate scope, tolerates carbonyl and amine functional groups, and liberates water as the only byproduct.

Efficient and general continuous-flow hydroarylation and hydroalkylation of styrenes

A simple and efficient continuous-flow hydroarylation of arenes and heteroarenes using various styrenes in conjunction with a heterogeneous catalyst has been developed. Additionally, this method has been successfully extended to the hydroalkylation of styrenes by employing 1,3-dicarbonyl compounds as the nucleophile. Multigram quantities of diarylmethanes have been prepared using this new flow method. Copyright

Iron-containing mesoporous aluminosilicate: A highly active and reusable heterogeneous catalyst for hydroarylation of styrenes

Hydroarylation of various styrene derivatives has been successfully carried out in excellent yield using Fe-Al-MCM-41 catalyst. The C-H functionalization using solid heterogeneous catalyst provides a straightforward access to a series of important 1,1-diarylalkane products. The catalyst can be recovered and reused at least three times without any significant loss in its catalytic activity.

Highly efficient iodine-catalyzed hydroarylation of arenes with styrenes

Iodine mediates the hydroarylation of styrenes with arenes and heteroarenes to afford 1,1-diarylalkanes in good to high yields. Details regarding the substrate scope and selectivity of this hydroarylation reaction are discussed.

An effective bismuth-catalyzed benzylation of arenes and heteroarenes

A highly efficient Bi(OTf)3-catalyzed benzylation of arenes and heteroarenes has been developed. The mild reaction conditions, high yields, operational simplicity and practicability, broad scope, and remarkably low catalyst loading render this environment friendly process an attractive approach to diarylmethane derivatives. The extension to an intramolecular variant of this procedure provides a valuable route to substituted fluorenes.

A convenient FeCl3-catalyzed hydroarylation of styrenes

(Chemical Equation Presented) 1,1-Diarylalkanes are easily synthesized by CH-functionalization reactions of electron-rich arenes and heteroarenes with styrenes in the presence of FeCl3 as catalyst.

Efficient metal-catalyzed hydroarylation of styrenes

A highly efficient metal-catalyzed hydroarylation of various styrenes has been developed. This new bismuth-catalyzed C-H functionalization provides straightforward access to a series of valuable 1,1-diarylalkane products.