10446-59-0

Upstream product

• 67-56-1 methanol 
• 39057-64-2 N,N′?(4?nitrobenzylidene)bisbenzamide 
• 1508299-99-7 N-(ethoxy(4-nitrophenyl)methyl)benzamide 
• 55-21-0 benzamide 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 39057-65-3 tert-butyl-[4-(4-nitro-phenyl)-2-phenyl-oxazol-5-yl]-amine 
• 1332628-28-0 (4S,6S,4aS,8aR)-acetic acid 7-acetoxymethyl-4-(4-nitro-phenyl)-2-phenyl-4a,6,7,8a-tetrahydro-4H,5H-pyrano[3,2-e][1,3]oxazin-6-yl ester 
• 1332628-38-2 (4S,5R,6S,7S,4aS,8aR)-acetic acid 3,4-bis-allyloxy-5-[benzoylamino-(4-nitrophenyl)-methyl]-6-methoxy-tetrahydro-pyran-2-ylmethyl ester 
• 1332628-43-9 (4S,5R,6R,8aR)-5,6-bis-allyloxy-7-allyloxymethyl-4-(4-nitro-phenyl)-2-phenyl-4a,6,7,8a-tetrahydro-4H,5H-pyrano[3,2-e][1,3]oxazine 
• 562099-92-7 N-[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-benzamide 

Relevant academic research and scientific papers

A palladium-catalyzed arylation of N-acyl-N,O-acetals with arylboronic reagents: Synthesis of diarylmethylamines protected by easily removable acyl group

An efficient process was developed to synthesis diarylmethylamines protected by a readily removable acyl group using a palladium-catalyzed arylation of N-acyl-N,O-acetals with arylboronic reagents. The attractive features of this protocol are: the ease of

Synthesis of N -acyl- N, O -acetals mediated by titanium ethoxide

N-Acyl-N,O-acetals are present in a number of bioactive natural products, and this unusual functional group can act as a synthetic precursor to unstable reactive N-acylimines. In this paper, a variety of N-acyl-O-ethyl-N,O-acetals was concisely prepared under mild conditions mediated by titanium ethoxide (Ti(OEt)4). The method also offers a new strategy to make other O-alkyl-N,O-acetals. Furthermore, this strategy was extended to the synthesis of an analogue of the natural product turtschamide.