10447-39-9 Usage
Uses
Used in Pharmaceutical Industry:
(3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE is used as a muscarinic acetylcholine receptor antagonist for its ability to selectively bind and block the muscarinic receptors, which play a crucial role in the parasympathetic nervous system. This property makes it a valuable compound for the development of drugs targeting various conditions, such as respiratory disorders, gastrointestinal motility issues, and urinary incontinence.
Used in Biological Studies:
In the field of biological research, (3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE serves as a valuable tool for studying the structure-activity relationships of muscarinic acetylcholine receptor antagonists. Its unique chemical structure allows researchers to investigate the interactions between these antagonists and their target receptors, leading to a better understanding of the underlying mechanisms and the development of more effective drugs.
Used in Drug Design and Development:
(3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE is utilized in the design and development of novel drugs targeting muscarinic acetylcholine receptors. Its specific binding properties and structural features make it a promising candidate for the creation of new therapeutic agents with improved efficacy, selectivity, and safety profiles. (3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE can be further modified or used as a template for the synthesis of related compounds with potential applications in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 10447-39-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,4 and 7 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10447-39:
(7*1)+(6*0)+(5*4)+(4*4)+(3*7)+(2*3)+(1*9)=79
79 % 10 = 9
So 10447-39-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO/c22-20(17-7-3-1-4-8-17,18-9-5-2-6-10-18)19-15-21-13-11-16(19)12-14-21/h1-10,16,19,22H,11-15H2
10447-39-9Relevant academic research and scientific papers
Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonists
Lainé, Dramane I.,McCleland, Brent,Thomas, Sonia,Neipp, Christopher,Underwood, Brian,Dufour, Jeremy,Widdowson, Katherine L.,Palovich, Michael R.,Blaney, Frank E.,Foley, James J.,Webb, Edward F.,Luttmann, Mark A.,Burman, Miriam,Belmonte, Kristen,Salmon, Michael
experimental part, p. 2493 - 2505 (2010/03/04)
A novel 4-hydroxyl(diphenyl)methyl substituted quinuclidine series was discovered as a very promising class of muscarinic antagonists. The structure-activity relationships of the connectivity of the diphenyl moiety to the quinuclidine core and around the ring nitrogen side chain are described. Computational docking studies using an homology model of the M3 receptor readily explained the observed structure-activity relationship of the various compounds. Compound 14o was identified as a very potent, slowly reversible M3 antagonist with a very long in vivo duration of bronchoprotection.
