1044766-47-3Relevant academic research and scientific papers
Total synthesis of (±)-platencin
Hayashida, Joji,Rawal, Viresh H.
, p. 4373 - 4376 (2008)
(Chemical Equation Presented) Resistant bacteria - beware! Platencin, a structurally novel broad-spectrum antibacterial agent, was the target of a total synthesis from o-anisic acid (see scheme). A Diels-Alder reaction with an a-substituted cyclohexenone as well as a [Ni-(cod)2]-promoted 1,4-addition enables the concise and stereocontrolled formation of the core. A protecting group free coupling with an aniline unit completed the synthesis. cod = 1,5-cyclooctadiene.
