104479-01-8

Basic information

• Product Name: N-(4-amino-2-benzoylphenyl)benzoic acid amide
• Synonyms: N-(4-amino-2-benzoylphenyl)benzoic acid amide
• CAS NO: 104479-01-8
• Molecular Weight: 316.359
• Mol File: 104479-01-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-amino-2-benzoylphenyl)benzoic acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-amino-2-benzoylphenyl)benzoic acid amide(104479-01-8)
• EPA Substance Registry System: N-(4-amino-2-benzoylphenyl)benzoic acid amide(104479-01-8)

Safety Data

• Hazardous Substances Data: 104479-01-8(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 1775-94-6 N-(2-benzoyl-4-nitrophenyl)benzamide 

Downstream Products

• 104479-09-6 C₂₅H₂₂N₄O₆ 

Relevant articles and documents

Structure-activity relationships of novel anti-malarial agents: Part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

We have developed the [5-(4-nitrophenyl)-2-furyl]acrylic acid substituted benzophenone 4g as a novel lead for anti-malarial agents. Here, we demonstrated that the acyl residue at the 2-amino group of the benzophenone core structure has to be a phenylacetic acid substructure substituted in its para-position with methyl or other substituents of similar size. The trifluoromethyl substituted derivative displayed an IC50 of 47 nM against the multi-drug resistant Plasmodium falciparum strain Dd2.

Synthesis, molecular modeling, and structure - Activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors

Because of the involvement of farnesylated proteins in oncogenesis, inhibition of the protein-modifying enzyme farnesyltransferase is considered a major emerging strategy in cancer therapy. Here, we describe the structure - activity relationship of a nove