104479-78-9

Basic information

• Product Name: 5-PyriMidinaMine, N-(phenylMethyl)-
• Synonyms: 5-PyriMidinaMine, N-(phenylMethyl)-;N-Benzylpyrimidin-5-amine
• CAS NO: 104479-78-9
• Molecular Formula: C₁₁H₁₁N₃
• Molecular Weight: 185.22514
• Mol File: 104479-78-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-PyriMidinaMine, N-(phenylMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-PyriMidinaMine, N-(phenylMethyl)-(104479-78-9)
• EPA Substance Registry System: 5-PyriMidinaMine, N-(phenylMethyl)-(104479-78-9)

Safety Data

• Hazardous Substances Data: 104479-78-9(Hazardous Substances Data)

Usage

General Description

5-Pyrimidinamine, N-(phenylmethyl)-, also known as PMPP, is a chemical compound with the molecular formula C12H11N3. It is an aromatic amine that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceuticals. PMPP is a white to light yellow solid with a melting point of 116-119°C, and it is soluble in organic solvents such as ethanol and diethyl ether. 5-Pyrimidinamine, N-(phenylmethyl)- may also have potential applications in the field of organic synthesis and medicinal chemistry due to its unique chemical structure and reactivity. Additionally, it is important to handle PMPP with caution and follow proper safety protocols when working with this chemical.

InChI:InChI=1S/C11H11N3/c1-2-4-10(5-3-1)6-14-11-7-12-9-13-8-11/h1-5,7-9,14H,6H2

Upstream product

• 4595-59-9 5-bromopyrimidine 
• 100-46-9 benzylamine 

Relevant articles and documents

d-Glucose: An Efficient Reducing Agent for a Copper(II)-Mediated Arylation of Primary Amines in Water

A copper-catalyzed Ullmann-type amination with primary amines in water with a combination of copper(II) triflate [Cu(OTf)2], dipivaloylmethane, and d-glucose is reported. The mild conditions and the use of an inexpensive catalyst as well as a renewable feedstock (d-glucose and the surfactant TPGS-750-M, which is derived from vitamin E) make this protocol a safe and convenient strategy for efficient C?N bond formation. This easy-to-handle procedure is extremely competitive compared to palladium-based reactions and may be used to synthesize N-containing molecules, such as drugs or organic light-emitting diodes (OLEDs).

Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPentCl Precatalyst

A single set of reaction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd-PEPPSI-IPentCl catalyst (PEPPSI=pyridine enhanced precatalyst preparation, stabilization, and initiation) with the soluble and nonaggressive sodium salt of BHT (BHT=2,6-di-tert-butyl-hydroxytoluene), both six- and five-membered (hetero)aryl halides undergo efficient and selective amination.

Highly efficient and practical phosphoramidite-copper catalysts for amination of aryl iodides and heteroaryl bromides with alkylamines and N(H)-heterocycles

A highly efficient copper-catalyzed system using phosphoramidite as ligands was applied to N-arylation of alkylamines and N(H)-heterocycles with aryl iodides and heteroaryl bromides. The reactions were carried out in relative mild conditions and good to excellent yields were obtained.