104484-42-6

Basic information

• Product Name: 6-ethyl-5-[3-nitro-4-(piperidin-1-yl)phenyl]pyrimidine-2,4-diamine
• Synonyms: 2,4-pyrimidinediamine, 6-ethyl-5-[3-nitro-4-(1-piperidinyl)phenyl]-
• CAS NO: 104484-42-6
• Molecular Formula: C₁₇H₂₂N₆O₂
• Molecular Weight: 342.3956
• Mol File: 104484-42-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 624.4°C at 760 mmHg
• Flash Point: 331.4°C
• Density: 1.303g/cm³
• Vapor Pressure: 1.65E-15mmHg at 25°C
• Refractive Index: 1.655
• CAS DataBase Reference: 6-ethyl-5-[3-nitro-4-(piperidin-1-yl)phenyl]pyrimidine-2,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-ethyl-5-[3-nitro-4-(piperidin-1-yl)phenyl]pyrimidine-2,4-diamine(104484-42-6)
• EPA Substance Registry System: 6-ethyl-5-[3-nitro-4-(piperidin-1-yl)phenyl]pyrimidine-2,4-diamine(104484-42-6)

Safety Data

• Hazardous Substances Data: 104484-42-6(Hazardous Substances Data)

Upstream product

• 58-14-0 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine 
• 110-89-4 piperidine 
• 21813-35-4 2,4-diamino-5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine 

Downstream Products

• 123240-47-1 5-(3-Azido-4-piperidin-1-yl-phenyl)-6-ethyl-pyrimidine-2,4-diamine 
• 123240-52-8 2,4-diamino-6-ethyl-5-(4-piperidinophenyl)pyrimidine 
• 123240-36-8 5-(3-Amino-4-piperidin-1-yl-phenyl)-6-ethyl-pyrimidine-2,4-diamine 

Relevant articles and documents

Structural Studies on Bioactive Compounds. 8. Synthesis, Crystal Structure, and Biological Properties of a New Series of 2,4-Diamino-5-aryl-6-ethylpyrimidine Dihydrofolate Reductase Inhibitors with in Vivo Activity against a Methotrexate-Resistant Tumor C

A series of 2,4-diamino-5-aryl-6-ethylpyrimidines embracing basic substituents in the 5-aryl ring was synthesized and evaluated for inhibitory activity against rat liver dihydrofolate reductase (DHFR).Maximal enzyme inhibition was observed for compounds b