104484-42-6Relevant articles and documents
Structural Studies on Bioactive Compounds. 8. Synthesis, Crystal Structure, and Biological Properties of a New Series of 2,4-Diamino-5-aryl-6-ethylpyrimidine Dihydrofolate Reductase Inhibitors with in Vivo Activity against a Methotrexate-Resistant Tumor C
Griffin, Roger J.,Meek, Michelle A.,Schwalbe, Carl H.,Stevens, Malcolm F. G.
, p. 2468 - 2474 (2007/10/02)
A series of 2,4-diamino-5-aryl-6-ethylpyrimidines embracing basic substituents in the 5-aryl ring was synthesized and evaluated for inhibitory activity against rat liver dihydrofolate reductase (DHFR).Maximal enzyme inhibition was observed for compounds b
Structural Studies on Bio-active Compounds. Part 3. Re-examination of the Hydrolysis of the Antimalarial Drug Pyrimethamine and Related Derivatives and Crystal Structure of a Hydrolysis Product
Griffin, Roger J.,Schwalbe, Carl H.,Stevens, Malcolm F. G.,Wong, Kait P.
, p. 2267 - 2276 (2007/10/02)
Hydrolysis of the diaminopyrimidine pyrimethamine and some of its 5-(3'-substituted)phenyl derivatives with 6M-hydrochloric acid or deamination with nitrous acid, affords mixtures of isomeric aminopyrimidinones.The ratio of products is influenced by the n
