104485-43-0

Upstream product

• 172944-57-9 (3S,4S)-4-((4S,5S)-4,5-Bis-methoxymethyl-2-methyl-[1,3]dioxolan-2-yl)-3-((R)-1-hydroxy-ethyl)-1-(4-methoxy-phenyl)-azetidin-2-one 
• 139308-11-5 (4S)-4-<(4S,5S)-4,5-dimethoxymethyl-2-methyl-1,3-dioxolan-2-yl>-1-p-methoxyphenyl-2-azetidinone 

Downstream Products

• 171782-15-3 (E)-4-[(2S,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-yl]-penta-2,4-dienoic acid ethyl ester 
• 104401-80-1 (3S,4S)-4-Acetyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-methoxy-phenyl)-azetidin-2-one 

Relevant academic research and scientific papers

Preparation method of azetidinone compound and preparation method 4 - acyloxy-azetidinone compound

The invention provides a preparation method of a azetidinone compound and a preparation method of 4 - acyloxy-azetidinone compound. The preparation method comprises the following steps S1, an epoxy amide compound reacts with I alkali reagents to form a ring reaction, and first 1st reaction systems are obtained. Step S2: The first reaction system is subjected to hydroxyl protection reaction with a raw material including a silanization reagent and a nitrogen-containing basic organic matter to obtain second reaction systems. In step S3, second reaction system and second base reagent are subjected to isomerization reaction to obtain the azetidinone compound, wherein the epoxy amide compound has the structure shown VI, the separation process of the isomer product of the structure shown II and formula III IV is avoided, and the selectivity and yield of the azetidinone compound are improved.

Dissociation method and application of titanium complex drug

The invention discloses a dissociation method and application of a titanium complex drug. According to the dissociation method, the stronger coordination property of citric acid and metal ions is utilized, the citric acid competes with drug molecules for coordination of titanium ions, the drug molecules complexed in the titanium complexation drug are released, and then separation operation is performed to collect the released drug molecules. According to the dissociation method disclosed by the invention, the purity of the drug compound can be obviously improved, because the citric acid can becompletely complexed with the titanium ions, a titanium complex formed by the drug molecules and the titanium ions is disintegrated, and then the dissociated drug compound is directly concentrated and collected through separation operation, so that the drug compound is obtained. The method is simple and efficient, the obtained drug compound has fewer impurities and higher purity, and the qualityof the drug is obviously improved.

4AA intermediate refining method

The invention discloses a 4AA intermediate refining method. According to the refining method, a 4AA intermediate (III) to be refined is added into a mixed solvent system composed of a solvent A and asolvent , after the 4AA intermediate is dissolved, the s

Hydrogenolysis-Isomerization-Reduction of Propargyl Acetate, and Regio- and Stereoselective Hydrogenation of Dienyl Ester for the Synthesis of 1β-Methylcarbapenem Precursor

A straightforward synthetic route of 1β-methylcarbapenem precursor is established by hydrogenolysis-isomerization-reduction process of propargyl acetate or by regio- and stereoselective hydrogenation process of dienyl ester with complete stereoselectivity