104485-84-9

Upstream product

• 6118-51-0 exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride 
• 67-56-1 methanol 

Downstream Products

• 112918-09-9 methyl 3-exo-(benzyloxycarbonylamino)-7-oxabicyclo<2.2.1>heptane-2-exo-carboxylate 
• 112918-10-2 2-exo-(benzyloxycarbonylamino)-3-endo-formyl-7-oxabicyclo<2.2.1>heptane 
• 112918-10-2 2-exo-(benzyloxycarbonylamino)-3-exo-formyl-7-oxabicyclo<2.2.1>heptane 
• 112918-11-3 ((1R,2S,3S,4S)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-carbamic acid benzyl ester 
• 6253-21-0 3α-hydroxymethyl-7α-oxabicyclo[2.2.1]heptane-2α-carboxylic acid lactone 

Relevant academic research and scientific papers

A flow chemistry approach to norcantharidin analogues

Acid-ester and acid-amide norcantharidin derivatives are prepared using a 'one-pot' synthetic procedure utilizing the ThalesNano H-cube flow hydrogenator. Traditionally, rapid library generation and reaction scale up of these analogues was limited by the batch wise hydrogenation of 5,6-dehydronorcantharidin. This was resolved with the use of flow chemistry. With no associated scale up issues, a method was devised to produce norcantharidin, along with acid-ester and acid-amide analogues on any scale necessary for biological screening.

[4 + 2] Cycloadditions of rigid s-cis dienes to C60. A synchronous Diels-Alder reaction

(Matrix presented) The Diels-Alder reaction of rigid s-cis dienes with C60 occurs by a concerted mechanism, via a symmetrical transition state.