104525-50-0

Basic information

• Product Name: [(2R,3S,4S,5R)-5-(6-Amino-purin-9-yl)-4-chloro-3-(2-chloro-phenylsulfanyl)-tetrahydro-furan-2-yl]-methanol
• CAS NO: 104525-50-0
• Molecular Weight: 412.299
• Mol File: 104525-50-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [(2R,3S,4S,5R)-5-(6-Amino-purin-9-yl)-4-chloro-3-(2-chloro-phenylsulfanyl)-tetrahydro-furan-2-yl]-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [(2R,3S,4S,5R)-5-(6-Amino-purin-9-yl)-4-chloro-3-(2-chloro-phenylsulfanyl)-tetrahydro-furan-2-yl]-methanol(104525-50-0)
• EPA Substance Registry System: [(2R,3S,4S,5R)-5-(6-Amino-purin-9-yl)-4-chloro-3-(2-chloro-phenylsulfanyl)-tetrahydro-furan-2-yl]-methanol(104525-50-0)

Safety Data

• Hazardous Substances Data: 104525-50-0(Hazardous Substances Data)

Upstream product

• 62805-48-5 9-(2,5-di-O-acetyl-3-bromo-3-deoxy-β-D-xylofuranosyl)-1,9-dihydro-6H-purine-6-one 
• 108194-68-9 6-N-dibenzoyl-9-(2',5'-di-O-acetyl-3'-deoxy-3'-bromo-β-D-xylofuranosyl)adenine 
• 6320-03-2 2-chlorothiphenol 
• 14575-10-1 o-chlorobenzenesulfenyl chloride 
• 108182-79-2 6-N-dibenzoyl-9-(5'-O-acetyl-2',3'-dideoxy-β-D-glycero-pent-2-enofuranosyl)adenine 

Downstream Products

• 108183-13-7 [(2S,5R)-5-(6-Amino-purin-9-yl)-4-(2-chloro-phenylsulfanyl)-2,5-dihydro-furan-2-yl]-methanol 
• 66224-66-6 adenine 

Relevant articles and documents

The Reaction of 9-(2',3'-Dideoxy-β-D-glycero-pent-2-Enofuranosyl)-adenine Derivatives with Arene- and Alkenesulfenyl Chlorides. An Unusual Ring Opening Reaction of Thiiranium Ions

A series of arenesulfenyl chlorides and methanesulfenyl chloride were reacted in pyridine solution with 6-N-dibenzoyl-9-(2',3'-dideoxy-β-D-glycero-pent-2-enofuranosyl)adenine (1b).In each case, the relative abundance of isomeric β-chloroarene/alkene sulfides was estimated and used to assess the relative thermodynamic stabilities of the lyxo and ribo thiiranium ion intermediates and their steric susceptibilities to attack by nucleophile (Cl-).Subsequently, the β-chloroarene/alkene sulfides 8a-d to 13 a-d, upon alkaline treatment, underwent an unprecedented ylide-mediated β elimination of the intermediary lyxo and ribo thiiranium ions, to give only 2'-ene-thiol ethers 14-19.