1045335-54-3Relevant academic research and scientific papers
An unprecedented approach to 4,5-disubstituted pyrimidine derivatives by a ZnCl2-catalyzed three-component coupling reaction
Sasada, Toshiaki,Kobayashi, Fuminori,Sakai, Norio,Konakahara, Takeo
supporting information; experimental part, p. 2161 - 2164 (2009/09/28)
We have developed a ZnCI2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.
